功能化多壁碳纳米管对四膜虫的生物效应研究  

Bio-effect of modified multi-wall carbon nanotubes on Tetrahymena pyriformis

作　　者：郭金学[1] 辛雪琼[1] 诸颖[2] 李文新[2] 

机构地区：[1]青岛科技大学化学与分子工程学院,青岛266042 [2]中国科学院上海应用物理研究所,上海201800

出　　处：《辐射研究与辐射工艺学报》2007年第6期326-329,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家973计划(2006CB705600)资助

摘　　要：利用癸胺和葡萄糖胺对吸收γ光子后的多壁碳纳米管进行化学修饰,得到表面修饰了不同浓度官能团的碳纳米管,这些碳纳米管能够分别溶解于有机溶剂和水。研究了功能化后的多壁碳纳米管对四膜虫(Tetrahymena pyriformis)的生物效应。结果显示,表面修饰了癸胺的碳纳米管对四膜虫的生长具有明显的抑制作用,而表面修饰了葡萄糖胺的碳纳米管则能够促进四膜虫的生长。进一步研究发现,γ光子通过提高碳纳米管表面修饰官能团的量,强化了它们对于四膜虫的生物效应。本工作在研究碳纳米管对单细胞生物所引起的生物效应方面做出了有益探索,并且为碳纳米管生物医药领域的应用提供了新思路。Multi-waUed carbon nanotubes （MWNTs） irradiated with y-rays were chemically modifified with glucosamine and decylamine, respectively. The cytotoxicity of Tetrahymena pyriformis exposured to irradiated MWNTs, MWNTs modifyed with giucosamine and decylamine （denoted by G-MWNTs and D-MWNTs） was carded out. The results indicated that MWNTs modified with different functional groups exhibited different bioactivity to Tetrahymena pyriformis. D-MWNTs showed a significant toxicity to Tetrahymena pyriformis, and the viability of cells reduced to 46.2%. And G-MWNTs promoted significantly the growth of cells, with the viability being up to 308%. More interestingly, it was shown that the toxicity and bioactivity of modified MWNTs to cells was changed along with the contents of functional groups bound on the surface of MWNTs. The studies may supply a possible strategy for enhancing or reducing the toxicity of MWNTs to meet certain applications in biological and medical field.

关 键 词：多壁碳纳米管 Γ射线 化学修饰 细胞毒性 四膜虫 

分 类 号：TB383[一般工业技术—材料科学与工程] X174[环境科学与工程—环境科学]