睾丸癌组织C-myc蛋白及ras基因产物p21蛋白表达评价  

Evaluation of Expression of p21 and C-myc Protein in Human Testis Cancer

作　　者：丁强[1] 张元芳[1] 施达仁[2] 

机构地区：[1]上海医科大学华山医院,上海200040 [2]上海医科大学肿瘤医院,上海200032

出　　处：《浙江肿瘤》1997年第1期36-36,共1页

摘　　要：目的；本文探讨人睾丸癌组织中C-myc蛋白及ras基因产物p21蛋白表达的临床意义。方法：应用C-myc和p21单克隆抗体，通过免疫组织化学方法检测5例正常睾丸组织和27例军丸癌组织中ras癌基因产物p21和C－myc蛋白的表达状况。结果：5例正常睾丸组织中未发现p21和C－myc蛋白阳性表达。阳性表达的p21和C－myc蛋白分别定位于肿瘤的细胞膜上和细胞核内。27例来扎癌中p21和C－myc蛋白阳性表达率分别为44.4％（12／27）和48.2％（13／27），并且与病理分级和临床分期相关。结论：提示p21和C－myc蛋白阳性表达在睾丸癌发生和发展中起着重要作用，可作为评价睾丸癌预后的新参数。Purpose: This paper aims to investigate the clinic significance of expression of p21 and C-myc protein in human testiscancer. Method: Authors of the paper performed the expression of C-myc and p21 proteins in 5 cases of normal testis tissues and 27 casestestis cancer tissues by immunohistochemical method. Results:p21 and C-myc proteins were Iocated in membrane and npclear respective-ly in testis cancer. The positive expression rates for testis cancer were 44. 4 % (12/27)and 48. 2 % (13/27)respectively, but no stainingwas found in 5 cases of normal testis tissues, and expression of p21 and C-myc proteins related to the staging and grade of testis cancer.Conclusion: Our studies suggest that expression of p21 and C-myc proteins play a important role in the development of testis cancer, andmay be a new indicator to assess the prognosis of testis cancer.

关 键 词：睾丸肿瘤 基因 RAS P21蛋白 C-MYC蛋白 

分 类 号：R737.210.2[医药卫生—肿瘤]