乳牙菌斑液短链有机酸含量与龋易感性的研究分析  

Relationship between Contents of Short Chain Organic Acids in Plaque Fluid of Primary Teeth and Caries Susceptibility

作　　者：梁惠霞[1] 石四箴[2] 葛久禹[1] 杨如美[1] 

机构地区：[1]南京大学医学院附属口腔医院口腔内科,江苏南京210008 [2]同济大学儿童口腔医学研究所

出　　处：《口腔医学研究》2007年第6期653-655,共3页Journal of Oral Science Research

摘　　要：目的:检测并研究蔗糖溶液漱口前后乳牙菌斑液乳酸、乙酸、丙酸含量与龋病易感性的关系。方法:32名3～5岁完整乳牙列幼儿,无龋组12例(dft=0且CSI=0),有龋组20例(dft(0且CSI(0)。用高效液相色谱仪分离测定10%蔗糖溶液漱口前后菌斑液中乳酸、乙酸、丙酸浓度。结果:10%蔗糖溶液漱口前后,有龋组与无龋组比较,菌斑液乳酸浓度差值有统计学意义(P<0.01)。有龋组漱口前后菌斑液乳酸浓度差值与dft、CSI呈正相关关系(r=0.455,P<0.05;r=0.474,P<0.05)。结论:蔗糖溶液漱口前后乳牙菌斑液乳酸含量的变化与个体龋易感性相关。Objective： To survey contents of lactic acid, acetic acid and propionic acid in dental plaque fluid of children before and after 10% sucrose solution rinse and study its relationship with caries susceptibility. Methods： 32 children aged 3 - 5 years with complete primary teeth were recorded by decayed or filled teeth （dft） and caries severity index（ CSI）, then were divided into two groups： caries-free group（dft =0 and CSI=0, n=12） and caries group （dft 〉 0 and CSI 〉 0,n = 20）. The contents of lactic acid, acetic acid and propionic acid in plaque fluid before and after 10% sucrose solution rinse were determined by high performance liquid chromatography. Results The increment of lactic acids of caries group was higher than that of caries - free group （ P 〈 0.05 ）. There was positive correlation between the increment of lactic acids and dft/CSI in caries group （ r = 0.455, P 〈 0.05 ; r = 0. 474, P 〈 0.05 ）. Conclusion ： There is correlation between the increment of lactic acid and the individual caries susceptibility.

关 键 词：乳牙 菌斑液 龋病 有机酸 高效液相色谱 

分 类 号：R780.2[医药卫生—口腔医学]