p57^(kip2)和cyclin D1在人脑胶质瘤中的表达和临床意义  

Expression of p57^(kip2) and cyclin D1 in human glioma and its clinical significance

作　　者：屈建强[1] 杨涛[2] 周乐[1] 张熙[1] 

机构地区：[1]西安交通大学医学院第二附属医院神经外科,陕西西安710004 [2]安康市中心医院神经外科,陕西安康725000

出　　处：《西安交通大学学报（医学版）》2007年第6期662-664,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科技计划基金资助项目[No.2006K09-G2(12)]

摘　　要：目的探讨p57kip2蛋白、cyclin D1蛋白在人脑胶质瘤中的表达情况及其临床意义。方法采用免疫组织化学SP法检测p57kip2、cyclin D1在55例人脑胶质瘤和10例正常脑组织中的表达。结果在55例胶质瘤中,p57kip2蛋白阳性率为38.2%(21/55),显著低于正常脑组织(80%,P<0.05)。p57kip2蛋白表达在低度恶性(Ⅰ-Ⅱ级)组显著高于高度恶性(Ⅲ-Ⅳ级)组(P<0.05),生存时间≥2年组显著高于<2年组(P<0.05)。脑胶质瘤中Cyclin D1蛋白阳性率为54.5%(30/55),显著高于正常脑组织(10%,P<0.05)。cyclin D1蛋白表达在高度恶性(Ⅲ-Ⅳ级)组显著高于低度恶性(Ⅰ-Ⅱ级)组(P<0.05),生存时间<2年组显著高于≥2年组(P<0.05)。p57kip2蛋白的表达与cyclinD1蛋白的表达存在负相关(rs=-0.277,P<0.05)。结论p57kip2蛋白和cyclin D1蛋白在脑胶质瘤中存在异常表达,p57kip2蛋白和cyclin D1蛋白的表达程度与脑胶质瘤的分化程度、预后相关。Objective To investigate the expression of p57^kip2 and cyclin D1 in human brain glioma and its clinical significance. Methods The expression of p57^kip2 and cyclin D1 was detected by SP immunohistochemical technique in brain glioma （n=55） and normal brain tissues （n = 10）. Results Positive rate of p57^kip2 protein in the 55 cases of brain glioma was 38.2% （21/55）, significantly lower than that in normal brain tissues （80%, P〈0.05）. p57^kip2 positivity in low malignancy group （ Ⅰ-Ⅱ grade） was significantly higher than that in high malignancy group （ Ⅲ- Ⅳ grade） （P〈0.05） ; in survival time ≥2 years group, it was significantly higher than that in 〈2 years group （P〈0.05）. Positive rate of cyclin D1 protein in brain glioma was 54.5 % （30/55）, significently higher than that in normal brain tissues （10%, P〈0. 05）. Cyclin D1 expression in high malignancy group （Ⅲ- Ⅳ grade） was significantly higher than that in low malignancy group （ Ⅰ- Ⅱ grade） （P〈0.01）; in survival time 〈2 years group it was significantly higher than that in ≥2 years group （P〈0.05）. There was a negative correlation between the expression of p57^kip2 and cyclin D1 （rs=-0. 277, P〈0.05）. Conclusion The expression of p57^kip2 protein and cyclin D1 protein is abnormal in glioma, and the expression extent is correlated with tumor differentiation and prognosis.

关 键 词：P57^KIP2蛋白 CYCLIN D1蛋白 脑胶质瘤 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]