营养与肿瘤表观遗传学关系的研究进展——DNA甲基化机制  

Relationship of nutrition with cancer and its epigenetic DNA methylation mechanism

作　　者：腾丽娟[1] 张长松[1] 李克[1] 

机构地区：[1]汕头大学医学院分子流行病学研究室,广东汕头515041

出　　处：《医学研究生学报》2008年第1期95-97,103,共4页Journal of Medical Postgraduates

基　　金：广东省自然科学基金资助项目(批准号:5300983)

摘　　要：DNA甲基化是目前研究最为深入的表观遗传学机制,在肿瘤细胞中基因组甲基化模式常常发生改变;作为甲基基团供体的营养素直接影响DNA甲基化的状况,与肿瘤的发生关系密切。作者着重阐述营养、甲基化和肿瘤三者的关系:描述甲基化和相关机制,探讨肿瘤在甲基化水平上发生、发展的分子机制,初步总结与甲基化相关的营养素在分子水平上对肿瘤发生、发展的影响机制,并在群体营养入水平上对肿瘤预防提出若干建议。DNA methylation is the best studied of the epigenetic changes that influence the gene expression, and changes in genomic methylation patterns have been observed in many cancer cell lines. Nutrients as methyl donors play essential roles in DNA methylation and may modify cancer risk. This review, with an emphasis on the relationship between nutrition, DNA methylation and cancer, firstly defines methylation with a description of its correlated mechanism, then approaches the molecular mechanism of cancer initiation and development at the methylation level, and lastly summarizes the mechanism underlying the effect of methylation-related nutrients on the process of cancer initiation and development at the molecular level. It also offers some suggestions on cancer prevention at the group nutrition level.

关 键 词：营养 肿瘤 DNA甲基化 

分 类 号：R735.1[医药卫生—肿瘤]