香菇多糖对荷瘤鼠淋巴器官和肿瘤生长的影响  

Effect of lentinan on lymphoid organ and tumor growing of tumor-bearing mice

作　　者：林卡莉[1] 邓婷[1] 陈同强[1] 况花荣[1] 

机构地区：[1]赣南医学院组织胚胎学教研室,江西赣州341000

出　　处：《赣南医学院学报》2007年第6期833-834,共2页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省卫生厅中医药科研基金资助项目课题(No:2006A67)

摘　　要：目的:探讨香菇多糖对小鼠S180移植性肿瘤的作用效果。方法:取昆明小鼠32只,分为正常盐水对照组,荷瘤空白对照组,荷瘤盐水对照组,荷瘤药物实验组。荷瘤小鼠是在小鼠右前腋皮下注射S180细胞悬液,制成实体瘤模型。香菇多糖采用腹腔注射给药。通过对小鼠体重、胸腺、脾脏指数以及肿瘤和肿瘤指数各项指标的测定分析,观察了香菇多糖的抑瘤效果及对荷瘤小鼠淋巴器官的影响。结果:(1)荷瘤药物实验组小鼠肿瘤生长缓慢。小鼠毛发较柔顺有光泽,更喜欢活动。(2)荷瘤鼠胸腺指数明显下降,香茹多糖可明显减轻这种抑制作用(P<0.05)。药物实验组小鼠的脾脏指数比正常盐水对照组及荷瘤空白对照组均有明显上升,P均<0.01。同时香茹多糖能抑制肿瘤的生长,抑瘤率达到47.85%。结论:香茹多糖能使荷瘤小鼠脾脏明显增大,并可减轻荷瘤小鼠胸腺重量的下降,提示香茹多糖能刺激宿主免疫细胞成熟、分化增殖,免疫功能恢复和提高,从而发挥对抗肿瘤的作用。Objective： To investigate the effects of lentinan on the mice with transplanted S180 sarcoma. Methods： 32 mice were divided into 4 groups： normal saline control group,tumor blank control group,tumor saline control group and tumor lentinan group. S180 sarcomas were transplanted into mice in tight axilla, lentinan was injected in tumor lentinan group, then observed the effect of lentinan on antitumor activity and influence on lymphoid organ, by testing indexes of thymus and spleen, as well as inhibitory rate of S180 tumor. Results： thymus index and spleen index in tumor lentinan group were gready higher than tumor blank control group（ P 〈 0.01 ）. Inhibition rates of S180 sarcoma in tumor lentinan group were 47.85%. Conclusion： lentinan can cause spleen of tumor - bearing mice growing and prevente the thymus weights from decreasing. It indicates lentinan can stimulate restoring and improving of immune function of tumor - beating mice.

关 键 词：香菇多糖 肿瘤 小白鼠 

分 类 号：R965[医药卫生—药理学]