正交设计在二苯甲基哌嗪制备中的应用  

THE APPLICATION OF ORTHOGONAL DESIGN IN SYNTHESIS OF BENZHYDRYLPIPERZINE

作　　者：谷建敏[1] 孟静[1] 杜秀芳[1] 杜玉民[1] 

机构地区：[1]河北医科大学药学院药物化学教研室,河北石家庄050017

出　　处：《河北医科大学学报》2008年第1期56-57,共2页Journal of Hebei Medical University

基　　金：国家高技术研究发展计划(863)资助项目(2002AA2Z3132)

摘　　要：目的对二苯甲基哌嗪的原工艺进行改进,并利用正交设计的方法对其条件进行优化。方法以二苯甲基氯和无水哌嗪为原料,无水乙醇做溶剂,两者经缩合制得二苯甲基哌嗪。结果成功地合成了目标化合物。结论对原工艺进行了改进,并对其条件进行了优化,提高了收率。Objective To improve synthesis method and the reaction condition of benzhydrylpiperazine by using orthogonal experimental design. Methods Benzhydrylpiperazine was synthesized by condensation of chlorodiphenylmethane and anhydrous piperazine in absolute ethanol. Results Benzhydrylpiperazine was synthesized successfully. Conclusion The result showed that it was easy and effective to get benzhydrylpiperazine and the purity and yield of benzhydrylpiperazine were good enough by this method.

关 键 词：二苯甲基哌嗪 正交实验 工艺学 

分 类 号：R914.5[医药卫生—药物化学]