阿魏酸酰胺类化合物的合成  

SYNTHESIS OF FERULIC ACID AMIDATING DERIVATIVE

作　　者：胡志忠[1] 田硕[2] 罗素琴[3] 赵冬冬[4] 刘乐乐[3] 

机构地区：[1]巴彦淖尔市医院药剂科,内蒙古巴彦淖尔015000 [2]中国人民解放军北京军区总医院263临床部 [3]内蒙古医学院药学院 [4]包头医学院

出　　处：《内蒙古医学院学报》2007年第6期407-410,共4页Acta Academiae Medicinae Neimongol

基　　金：内蒙古卫生厅资助项目(2006014)

摘　　要：目的:阿魏酸对环氧合酶(COX)的抑制具有选择性。对阿魏酸进行结构修饰,以期望得到有更强消炎活性、对COX-2有较高选择性、代谢稳定且毒副作用较小的化合物。方法:以香草醛为主要原料,经溴化、knoevenagel反应、乙酰化、酰氯化、酰胺化五步反应,合成目标化合物。结果与结论:合成1个化合物,用红外光谱进行结构表征,分析证实所合成的化合物与预期结构一致。Objective： Ferulic acid has selectivity of restraining cyclooxygenase （COX）. Through structural modification of ferulic acid, expecting compounds of having stronger antiinflammatory activity, higher selectivity of COX - 2, steadily metabolizing and small side effect can be found. Methods： Using vaniHin as the initial materials, the target compounds were prepared in five steps including bromination, knoevenagel reaction, acetylation, acylchloridization, and amidation. Results and Conclusion： One target compound was synthesized. The structure of all the target compounds was identified by infrared spectrum（IR） ,which were conform to the expected structure.

关 键 词：阿魏酸 合成 消炎 

分 类 号：R914.5[医药卫生—药物化学]