胃癌中RhoC和CD44v6的表达及其临床意义  

Expressions and Clinical Significance of RhoC and CD44v6 in Gastric Carcinoma

作　　者：王萍[1] 杨金凤[1] 张庆[2] 承泽农[1] 于东红[1] 

机构地区：[1]安徽省感染与免疫重点实验室,蚌埠医学院病理学教研室,安徽蚌埠233003 [2]蚌埠医学院附属医院中心实验室,安徽蚌埠233004

出　　处：《癌变．畸变．突变》2008年第1期60-63,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：安徽省教育厅自然科学研究项目(2005kj378zc)

摘　　要：背景与目的:探讨Ras相似蛋白C(Ras homologue C,RhoC)和CD44剪接变异体v6(CD44splice variant V6,CD44v6)在胃癌中的表达及其与临床病理因素之间的关系。材料与方法:采用免疫组化SP法检测97例胃癌组织中RhoC和CD44v6的表达情况。结果:97例胃癌组织中RhoC和CD44v6阳性率分别为77.31%(75/97)、83.50%(81/97),两者表达存在相关性(P<0.05)。RhoC和CD44v6表达均与胃癌的浸润深度和肿瘤分期有关(P<0.05),且淋巴结转移组RhoC表达显著高于无淋巴结转移组(P<0.05)。结论:RhoC和CD44v6蛋白的过量表达是胃癌的发生发展中的频发事件,可以作为判断预后的指标之一。BACKGROUND AND AIM： To investigate the expressions of RhoC and CD44v6 proteins in gastric carcinoma （GC） and their relationship to clinicopathological factors. MATERLALS AND METHODS： Immunohistochemi staining SP method was used to evaluate the expressions of RhoC and CD44v6 in 97 cases of GC. RKSULTS： 75（77.31% ） and 81 （83.50%） of 97 cases showed overexpressions for RhoC and CD44v6, respectively. There was a significant correlation between the overexpression of RhoC and CD44v6 （P 〈 0.05） The expressions of RhoC and CD44v6 in GC were significantly associated with the depth of tumor invasion and TNM staging（P〈0.05） Moreover, the RhoC overexpression was associated with lymph node metastasis（P 〈 0.05）. CONCLUSION： Overexpressions of RhoC and CD44v6 proteins are frequent events in GC. Measurement of these protein expressions might be used as a prognostic indicator for GC.

关 键 词：胃癌 RHOC CD44V6 侵袭 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]