限制能量摄入对老龄大鼠抗衰老效应的实验研究  

THE EXPERIMENTAL STUDY ON ANTI-AGING EFFECT OF CALORIC RESTRICTION

作　　者：李琳琳[1,2] 韩圣娜[3] 蒋卓勤[4] 

机构地区：[1]郑州大学公共卫生学院 [2]中山大学公共卫生学院营养系,广州510080 [3]郑州大学基础医学院 [4]中山大学公共卫生学院营养系

出　　处：《营养学报》2008年第1期35-38,共4页Acta Nutrimenta Sinica

摘　　要：目的研究限制能量摄入对老龄大鼠抗衰老的生物效应,并探讨其可能机制。方法雄性11月龄大鼠34只,随机分为三组,分别给予实验组大鼠对照组食量的80%和60%,6个月后测量血清SOD,MDA,IL-2,脑组织MAO,NO及肝细胞凋亡指数。结果实验组大鼠血清SOD,IL-2水平,脑组织NO含量较对照组明显提高;血清MDA水平,脑组织MAO活性,肝细胞凋亡指数较对照组显著降低。结论自老龄期开始限制能量的摄入,具有抗衰老的生物学效应。Objective To study the anti-aging effect of caloric restriction in aged rats. Method Thirty-four male aged SD rats were randomly divided into 3 groups. The experimental groups were given 80% and 60% diet of the control respectively. After 6 months we measured serum SOD, MDA, IL-2, the activity of NO, MAO in brain tissue and apoptosis index of hepatocytes. Results The activities of NO in brain tissue, SOD and IL-2 in serum in experimental groups were significantly higher than those in control group. Serum MDA, MAO of brain tissue and apoptosis index of hepatocytes in experimental groups were lower than those in control. Conclusion Caloric restriction shows anti-aging biological effects in aged rats. [ACTA NUTRIMENTA SINICA, 2008,30（1）： 35-38]

关 键 词：能量限制 衰老 生物学效应 

分 类 号：R151[医药卫生—营养与食品卫生学]