外周性原始神经外胚层肿瘤皮下埋植式动脉化疗的临床观察  

Clinical observation on intra-arterial chemotherapy by subcutaneous implantable delivery system for treatment of peripheral primitive neuroectodermal tumors

作　　者：范海涛[1] 李鼎锋[1] 刘蜀彬[1] 王磊[1] 崔秋[1] 张平[1] 周举[1] 刘铖[1] 姜维浩[1] 曹云岑[1] 

机构地区：[1]军事医学科学院附属解放军307医院骨科,北京100071

出　　处：《中国肿瘤临床与康复》2008年第1期38-41,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察外周性原始性神经外胚层肿瘤(pPNET)皮下埋植式动脉化疗的疗效。方法外周性原始神经外胚层肿瘤8例,男6例,女2例;中位年龄12.4岁。经皮下埋植式给药装置行阿霉素、顺铂联合咖啡因导向性灌注3～4次,化疗后进行手术或放射综合治疗。结果化疗后疼痛完全缓解;肿瘤病灶CR3例,PR5例,有效率100%。平均生存28.4个月,生存率37.5%。结论pPNET是一种极度恶性的小圆细胞肿瘤,皮下埋植式动脉化疗是一种有效的化疗方法,但还要辅以手术和放射治疗。Objective To observe the clinical results of intra-arterial chemotherapy by subcutaneous implantable delivery system in the treatment of perpheral primitive neuroectodermal tumours （pPNETs）. Methods Eight cases of pPNET（male 6 cases, female 2 cases, average age was 12.4 years ） were treated with cisplatin, adriamycin and caffeine targeting infusion by subcutaneous implantable intra-arterial drug delivery system for 3-4 times. Operation or radiation was given after chemotherapy. Results Total effective rate （CR） of relieving pain was 100%. CR of tumor was found in 3 cases,PR 5 cases,RR 100%. Average survival period was 28.4 months, rate of survival was 37.5%. Conclusion pPNET is a kind of malignant small round cell tumor with rapid aggressive clinical course. Intra-arterial chemotherapy by subcutaneous implantable delivery system is an effective treatment method. Operation or radiation is also necessary for auxiliary treatment.

关 键 词：外周性原始神经外胚层肿瘤 介入化疗 咖啡因 

分 类 号：R730.5[医药卫生—肿瘤]