软组织恶性纤维组织细胞瘤化疗的临床观察  

Clinical observations on preoperative chemotherapy of recurrent soft tissue malignant fibrous histiocytoma

作　　者：张平[1] 李鼎锋[1] 刘蜀彬[1] 张斌[1] 范海涛[1] 王磊[1] 崔秋[1] 周举[1] 刘铖[1] 曹云岑[1] 

机构地区：[1]军事医学科学院附属医院解放军307医院骨科,北京100071

出　　处：《中国肿瘤临床与康复》2008年第1期58-61,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察软组织恶性纤维组织细胞瘤动脉灌注化疗的疗效。方法44例软组织恶性纤维组织细胞瘤,采用皮下埋植式动脉介入化疗系统,用阿霉素和顺铂联合咖啡因、去甲斑蝥素治疗,治疗后随访32个月。结果本组病变影像改变PR18例(56.3%)。化疗后手术病理中重度以上化疗反应30例(71.4%)。平均随访32个月,术后无肿瘤局部复发。肺转移3例,2例死亡。结论软组织恶性纤维组织细胞瘤的治疗可以选择动脉灌注化疗,以化疗后手术切除的肿瘤病理改变作为重要的预后评价标准。Objective To investigate the efficacy of intra-arterial chemotherapy in treatment of soft tissue malignant fibrous histiocytoma（ MFH ）. Methods Forty-four patients with soft tissue MFH received the treatment of preoperative intra-arterial chemotherapy. Intra-arterial chemotherapy was given by subcutane- ous implantable drug delivery system with infusion of eisplatin and doxorubiein followed by caffeine and noreantharidin. After treatment,the patients were followed up for 32 months. Results The MFH changes in CT imaging were observed in 18 cases and medium or severe pathological changes caused by chemotherapy were found in 30 cases. At the end of the postoperative follow-up for 32 months, no local recurrence of MFH occurred. Pulmonary metastasis occurred in 3 cases and death in 2 cases. Condnsion Preoperative intra-arterial chemotherapy is effective for highly malignant tumors such as soft tissue MFH and the judgment of prognosis is based on the postoperative pathological changes of such tumor.

关 键 词：埋植式动脉介入化疗 恶性纤维组织细胞瘤 咖啡因 去甲斑蝥素 

分 类 号：R738[医药卫生—肿瘤]