p27^(kipl)和p57^(kip2)与CyclinD1在急性白血病的表达及其临床意义  

The expression and clinical significance of p27^(kipl),p57^(kip2) and CyclinD1 in acute leukemia

作　　者：王凡平[1] 孙志强[2] 李辰蕊[2] 景本年[2] 王明永[1] 

机构地区：[1]新乡医学院医学检验系,河南新乡453003 [2]贵阳医学院附属医院血液科

出　　处：《临床血液学杂志》2008年第1期22-24,共3页Journal of Clinical Hematology

摘　　要：目的:探讨p27kipl和p57kip2与CyclinD1在急性白血病中的表达情况及其临床意义。方法:采用免疫组化S-P法检测39例急性白血病及10例正常对照者骨髓中p27kipl和p57kip2与CyclinD1蛋白的表达情况,并结合临床病理资料进行分析。结果:p27kipl和p57kip2与CyclinD1蛋白在急性白血病患者的阳性表达率分别为31%、33%、54%,在对照组表达率为70%、40%、0。p27kipl与cyclinD1在白血病与对照组中的表达差异有统计学意义。在37例接受化疗的急性白血病中,p27kipl和p57kip2阳性表达组化疗后的缓解率(66%、69%)明显高于p27kipl和p57kip2表达阴性组的缓解率(32%、29%),其差异有统计学意义(P<0.05)。p57kip2与CyclinD1在白血病中的表达具有正相关性。结论:p27kipl和p57kip2与CyclinD1在急性白血病患者中存在异常表达其蛋白的表达水平可能会影响化疗疗效。Objective：To study the expression and clinical significance of p27^kip1, p57^kip2, CyclinD1 in acute leukemia（AL）. Method：The expression of p27^kip1, p57^kip2, CyelinD1 was measured in bone marrow samples of 39 AL and 10 cases in control groups by S-P immunohistochemistry method. Result： The expression of p27^kip1, p57^kip2 , CyclinD1 is 31%, 33 %, 50~~ in patients with acute leukemia, while 70%, 40%,0 ~ in control group. There was significant difference in expression of p27kjpj and CyclinD1 between AL and control groups. Significant expression of p27^kip1 and p57klp2 was detected using remission ratio of therapy. The expression of p27^kip1, p57klp2 and CyclinD1 ap- peared no correlation with sex,age, white blood cell number. There was positive correlation between p57^kip2 and CyclinD1. Conclusion：The expressions of p27^kip1, p57^kip2 and CyclinD1 were abnormal in acute leukemia, and may be a marker of the therapeutic effect.

关 键 词：P27^KIPL P57^KIP2 CYCLIND1 白血病 急性 

分 类 号：R733.7[医药卫生—肿瘤]