日粮中霉菌毒素引发小熊猫中毒性肝炎的临床调查  

Clinical investigation of toxic hepatitis of red pandas (Ailurus fulgens) induced by mycotoxins in diet

作　　者：修云芳 邵良平[2] 徐素慧 王德春[3] 陈婷 翁妮娜 陈玉村 

机构地区：[1]福州大熊猫研究中心,福州350001 [2]福建农林大学动物科学学院,福州350025 [3]南京军区福州总医院,福州350001 [4]福建农产品质量安全检验检测中心,福州350001

出　　处：《兽类学报》2008年第1期92-95,共4页Acta Theriologica Sinica

基　　金：福建省生物技术科技项目(2000Z156)

摘　　要：本文报道了小熊猫霉菌毒素中毒性肝炎的群发病案。35只小熊猫中,21只发病,5只死亡。通过日粮成分调查,饲料中霉菌毒素检测,病原微生物检查,血液参数测定,病理学检查和动物试验,确诊为呕吐毒素(DON)和玉米赤霉烯酮(F-2)毒素中毒。依据调查结果对小熊猫进行治疗,小熊猫预后良好。结论:(1)小熊猫对霉菌毒素(DON和F-2毒素)极其敏感,应予以高度重视;(2)DON和F-2毒素存在相互增强作用,对小熊猫的毒性作用主要为肝毒性和肾毒性,并可导致小熊猫机体免疫功能降低;(3)小熊猫对霉菌毒素的耐受性与环境的适应性有关,应激因素能提高小熊猫对霉菌毒素的敏感性。Cases of toxic hepatitis of red pandas （Ailurus fulgens） induced by mycotoxins in diet were reported in this paper. 21 red panda were suffered and 5 died among 35 animals. Composition and mycotoxins of diet, pathogens, clinical signs, blood parameters, necropsy and histopathological findings were investigated and recorded. And experimental toxicosis of mice was conducted by feeding the contaminated diet. Treatment was implemented guided by the result of investigation and prognosis was good. The study indicates that there should have toxicological interactions between DON and F-2 toxin in diet and their target organs are liver and kidney. The tolerance to mycotoxins of red pandas was certainly related to their adaptability to environment and stressors would increase the susceptibility of mycotoxins in red pandas and it is necessary to pay attention that the animal is very susceptible to mycotoxins.

关 键 词：小熊猫 霉菌毒素 玉米赤霉烯酮 呕吐毒素 

分 类 号：Q851.3[生物学]