Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery  

作　　者：Qing Lin Jiang Li Hai Lei Chen Jiao Lu Zhi Rong Zhang Yong Wu 

机构地区：[1]Key Laboratory of Drug Targeting of Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

出　　处：《Chinese Chemical Letters》2008年第2期127-129,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30672537);Ministry of Education of PR China(No.20050610085).

摘　　要：A novel bifunctional glycolipid which carded a cluster of thiogalactosides as the hepatocyte targeting ligand for gene delivery was prepared. Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly（ethylene glycol） chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce pentaantennary galactoside. Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.A novel bifunctional glycolipid which carded a cluster of thiogalactosides as the hepatocyte targeting ligand for gene delivery was prepared. Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly（ethylene glycol） chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce pentaantennary galactoside. Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.

关 键 词：Clustered glycosides TARGETING Galactosylated ligand HEPATOCYTE Gene delivery 

分 类 号：TQ31[化学工程—高聚物工业]