Fascin在口腔鳞癌中的表达及临床意义  

Expression of Fascin and its Significance in Oral Squamous Cell Carcinoma

作　　者：王德明[1] 赵尔飏[2] 吴衍昌[1] 王伟[1] 李芳[1] 

机构地区：[1]哈尔滨医科大学口腔医学院口腔颌面外科 [2]哈尔滨医科大学口腔医学院口腔病理教研室,黑龙江哈尔滨150001

出　　处：《口腔颌面外科杂志》2008年第1期11-14,共4页Journal of Oral and Maxillofacial Surgery

摘　　要：目的:研究Fascin在口腔鳞癌患者中的表达,以期为口腔鳞癌找到一个肿瘤标志物和靶向治疗的新靶标。方法:使用免疫组化Max Vision两步法观察Fascin在56例口腔鳞癌患者和12例口腔黏膜良性病变中的表达。结果:Fascin在口腔鳞癌中高表达(P=0.003)。Fascin的表达和肿瘤的临床分期(P=0.006),组织学分级(P=0.024),淋巴结转移(P=0.021)有关,与患者的性别(P=0.514)和年龄(P=0.474)无关。Fascin的染色强度与临床分期(P=0.041)和淋巴结转移(P=0.044)有关。Fascin高表达与低表达患者的生存率间有显著差异(P=0.030)。结论:Fascin可以作为口腔鳞癌有参考意义的肿瘤标志物,且可能和患者的不良预后有关,有望成为口腔鳞癌治疗的新靶标。Objective： To study the expression of Fascin in oral squamous cell carcinoma （OSCC）, in order to find a novel biomarker and therapeutic strategy. Methods： Paraffin section of 56 patients with OSCC and 12 benign hyperplasia tissues of oral mucosa were immunohistochemically investigated using monoclonal anti-Fascin antibody. Results Overexpression of Fascin was found in OSCC comparing with benign hyperplasia tissues （P=-0.003）. Fascin overexpression was closely related with the stage of tumor （P=0.006）, histology grade （P=0.024）, and lymph node metastasis （P=0.021）. The staining intensity of Fascin correlated with the stage of tumor（P=0.041） and lymph node metastasis（P=0.044）. Fascin overexpression was significantly associated with a poor prognosis（P=0.030）. Conclusion： Fascin overexpression may play an important role in the progression of OSCC. Tumor-specific Fascin down-regulation may become a novel therapeutic strategy to OSCC patients.

关 键 词：FASCIN 口腔癌 免疫组化 病理学 

分 类 号：R739.8[医药卫生—肿瘤]