广泛性焦虑注意网络的功能评估  

Study of attention networks impariment in patients with generalized anxiety disorder

作　　者：高莉玲[1] 董毅[2] 汪凯[1] 张志军[2] 季益富[2] 周珊珊[1] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022 [2]安徽省精神卫生中心,合肥230022

出　　处：《安徽医科大学学报》2008年第1期105-108,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:30370479;030670706);“973”项目子课题(编号:2005CB522800);安徽省教育厅重点自然科学基金(编号:2004kj192zd);安徽省优秀青年科技基金(编号:04043071)

摘　　要：目的探索广泛性焦虑(GAD)注意缺陷的特征。方法对确诊的30例GAD患者进行注意网络测试(ANT)和汉密尔顿焦虑量表(HAMA)的临床症状评定,并与30名正常对照组(n=30)的ANT结果相比较。结果GAD组执行控制网络时间[(117.37±28.84)ms]较正常对照组[(98.70±33.40)ms]明显延长,差异有显著性(P<0.05),而警觉网络和定向网络效率[(23.47±23.02)ms,(41.17±19.72)ms]与对照组[(21.63±15.89)ms,(48.33±23.56)ms]的差异无显著性(P>0.05)。平均反应时和平均正确率亦无明显差异。GAD患者警觉网络、定向网络与及执行控制网络效率与年龄无相关性。结论GAD患者执行控制网络受损,警觉网络和定向网络功能保留。Objective To investigate the attention networks （alerting, orienting, and executive control ）impairment in patients with generalized anxiety disorder. Method 30 patients met CCMD-3 criteria for generalized anxiety disorder （GAD） were tested with attention network test and HAMA before receiving treatment, the performance of attention networks in GAD（ n = 30） were compared with that of normal controls （ n = 30）. Results GAD patients showed significant deficits in the executive control networks effect compared to that of normal controls. The alerting and orienting networks effects and the correct rate of attention network test had no significant difference （ P 〉 0. 05）. There was no significant correlation with age. Conclusion Impairment of executive control network was found in GAD patients. The alerting and orienting networks were not impaired.

关 键 词：焦虑症 注意力 神经网 认知障碍 

分 类 号：R749.72[医药卫生—神经病学与精神病学] R395[医药卫生—临床医学]