瞬时感受器电位通道在呼吸系统的表达与功能  

Expression and function of transient receptor potential vanilloid - related channels on respiratory system

作　　者：王跃秀[1] 王辰[2] 王军[1] 

机构地区：[1]首都医科大学基础医学院生理学教研室,北京100069 [2]首都医科大学附属北京朝阳医院北京呼吸疾病研究所,100020

出　　处：《国际呼吸杂志》2008年第6期372-375,共4页International Journal of Respiration

基　　金：北京市教委基金项目（KM200710025002）;北京市自然科学基金项目（7072010）

摘　　要：野香草型瞬时感受器电位（TRPV）通道在人和动物呼吸系统中有着较广泛的表达。愈来愈多的研究表明：这些阳离子通道，特别是TRPV1和TRPV4在调节呼吸系统各功能中起举足轻重的作用。这些TRPV通道不但可被许多内源性物质激活，而且可被生理条件如pH值、体温、渗透压等的改变激活。TRPV通道的激活可诱发细胞钙内流，进而诱发生理及疾病状态下呼吸系统的功能调节。本文拟就其在呼吸系统的表达及功能研究进展进行简要回顾。Transient receptor potential vanilloid-related（TRPV） channels are generally expressed in several cell types in human and animal respiratory system. Increasing evidence has demonstrated the important roles of these cation channels, particularly TRPV1 and TRPV4, in the regulation of respiratory function. These TRPVs channel can be activated not only by a number of endogenous substances （hydrogen ion,certain lipoxygenase products,etc）,but also by the changes in physiological conditions （e. g. pH value, temperature,osmolarity,etc）. Activation of these channels can evoke Ca^2＋ influx and subsequently induce functional accommodation under the physiological or pathological condition. This review focuses primarily on the advancement of study about function of TRPV1 and TRPV4 expressed in the respiratory system.

关 键 词：呼吸系统 表达 生理功能 瞬时感受器电位通道 分类 蛋白结构 

分 类 号：R3[医药卫生—基础医学]