ABCC家族基因变异性研究进展  

Research progress on gene variants of the ABCC family

作　　者：尹继业[1] 刘昭前[1] 

机构地区：[1]中南大学临床药理研究所

出　　处：《中国临床药理学与治疗学》2008年第2期220-227,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(30572230);教育部新世纪优秀人才支持计划NCET-04-0749)

摘　　要：ATP结合盒亚家族C(ATP-Binding Cassette,Subfamily C,ABCC)蛋白家族是新近发现的一个较大的蛋白家族。该家族目前由9个成员所组成,在人体内分布广泛,参与机体内一些重要物质的转运。同时许多化疗药物也是它们的转运底物,其过度表达往往与肿瘤的多药耐药密切相关。最新研究表明,ABCC基因变异可以导致机体内物质代谢的改变和肿瘤耐药程度的改变,有的甚至可以直接导致遗传性疾病的产生。本文对AB-CC家族变异现象及其与肿瘤多药耐药的关系作一综述。The ABCC （ATP-Binding Cassette, Subfamily C, ABCC） family is a large protein family discovered recently. It is comprised of nine members which distribute widely in human body and participate in the tmnsportion of many important substmtes. Some chemotherapeutic agents are also substrates of ABCC whose over-expressions have been proved to be associated with muhidrug resistance. Recently, some studies showed that some mutations of ABCC family could affect the substance metabolism and lead to tumor multidrug resistance, even result in genetic disorders. The genetic variants of the ABCC family and their association with tumor multidrug resistance were reviewed in this paper.

关 键 词：ABCC家族 基因变异 多药耐药 多态性 

分 类 号：R730[医药卫生—肿瘤]