2005年中国食源性单核细胞增生李斯特菌耐药性趋势分析  

Analysis of antibiotic susceptibility of Foodborne listeria monocytogenes in China

作　　者：杨洋[1] 付萍[1] 郭云昌[1] 刘秀梅[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050

出　　处：《卫生研究》2008年第2期183-186,共4页Journal of Hygiene Research

基　　金：国家"十一五"科技支撑资助项目(2006BAK02A15);国际科技合作项目(No.2006DFA31470)

摘　　要：目的研究中国食源性单核细胞增生李斯特菌的药物敏感和耐药性。方法采用微量肉汤稀释法测定了467株食源性单核细胞增生李斯特菌对庆大霉素、氨苄西林、青霉素、四环素、强力霉素、亚胺培南、红霉素、环丙沙星、左旋氧氟沙星、头孢噻吩、利福平、万古霉素、氯霉素、氨苄西林/舒巴坦酸、复方新诺明15种抗生素的药敏结果。结果467株单核细胞增生李斯特菌耐药率为4.5%,主要耐受四环素和环丙沙星,四环素耐受最严重,耐药率达4.07%。在7类食品中,分离自蔬菜的单核细胞增生李斯特菌的耐药率最高,为10%。在14个省市中,吉林、湖北、河北的耐药率居前3位,分别为19.6%,9.1%,8%。结论中国食源性单核细胞增生李斯特菌存在耐药株,分离自不同食品、不同省份的单核细胞增生李斯特菌耐药性存在差异,应加强对预防用药和临床用药的重视,以减少单核细胞增生李斯特菌耐药性的增加。Objective To study the antibiotic susceptibility of foodborne Listeria monocytogenes in China. Methods The susceptibilities of 476 strains of foodborne Listeria monocytogenes to antibiotics were determined in Broth Microdilution Susceptibility Testing in Clinical and Laboratory Standards Institute. The antibiotics of gentamicin, ampicillin, penicillin, tetracycline, doxycycline, imipenem, erythromycin, ciprofloxacin, levofloxacin, cephalothin, rifampin, vancomycin, chloramphenicol, Trimethoprim-sulfamethoxazole, ampicillin-sulbactam were used. Results The rates of antibiotic resistance in 467 is olates were 4.5 %. Tetracycline resistance was most prevalent, accouting for 4.07 %. The foods that the rates of antibiotic resistance were highest were vegetable （10%）. Among 14 previnces, Jilin, Hubei and Hebei were the third top, the rate of which were 19.6 % and 9.1% and 8 %, respectively. Conclusion It was suggested that antibiotic resistance exists in foodborne Listeria monocytogenes to a certain extent in China. It should pay more attention to the use of drugs in prevention and clinic treatment to reduce the antibiotic resistant strains.

关 键 词：食源性单核细胞增生李斯特菌 药物敏感性微量肉汤稀释法 李斯特菌 食源性疾病 

分 类 号：R155.3[医药卫生—营养与食品卫生学] TS207.4[医药卫生—公共卫生与预防医学]