结肠癌单克隆抗体SC13A在鉴别卵巢癌系原发抑继发的作用  

The Role of Monoclonal Antibody SC13A in Differential Diagnosis of Primary Cancer and Metastasis in Ovary

作　　者：宋和存[1] 郭毅[1] 常文庆[1] 刘民培[2] 

机构地区：[1]中国医科大学第一临床学院妇科,沈阳市110001 [2]沈阳军区总医院医学实验科

出　　处：《中国肿瘤临床》1997年第8期599-601,共3页Chinese Journal of Clinical Oncology

基　　金：辽宁省科委基金

摘　　要：作者以可识别人结肠癌相关抗原的单克隆抗体SC13A为探针，对卵巢原发肿瘤和继发肿瘤进行免疫组化研究（SP法）。试图区别卵巢原发、继发肿瘤间是否存在不相同的抗原决定簇，探讨其在鉴别卵巢原发与继发肿瘤中的诊断价值。结呆是原发恶性卵巢肿瘤的抗原表达率为6％（3／52），与继发性卵巢肿瘤的抗原表达率88％（23／26）相比较，存在明显差异，有极显著性意义（P＜0．001）。在继发性卵巢肿瘤中，胃肠道源的转移癌其抗原表达率100％（n＝23），而来源于生殖道的子宫体转移癌无抗原表达（n＝3）。提示卵巢原发肿瘤与胃肠道转移肿瘤间具有不相同的抗原决定簇，并可对鉴别原发与继发性卵巢癌的诊断有较重要的临床意义。An immunohistochemical study was made in distinguishing primary from metastatic ovarian cancer by using monoclonal antibody SC13A. It was shown that the positive staining rate in primary ovarian cancer was 6% (3/52),while in metastatic ovarian cancer it was 88% (23/26, P<0.001). Among the metastatic cancers,the positive staining rate of the tumors originated from gastrointestinal cancer was 100% (n=23),while none of the 3 metastatic tumors from uterine cancer was positive. These results suggest that SC12A can be used in localizing the origin of the metastatic ovarian cancers besides distinguish primary or metastatic ovarian cancer.

关 键 词：卵巢肿瘤 单克隆抗体 结肠癌相关抗原 诊断 

分 类 号：R737.31[医药卫生—肿瘤]