经典型苯丙酮尿症患儿微量元素水平分析  

Analysis of nutritional status in children with classical type phenylketonuria

作　　者：张立琴[1] 傅平[1] 于双玉 周继勇[1] 

机构地区：[1]青岛市妇女儿童医疗保健中心,山东青岛266011

出　　处：《中国儿童保健杂志》2008年第2期213-214,共2页Chinese Journal of Child Health Care

基　　金：青岛市科技局科研项目(05-ZN5-42)

摘　　要：【目的】探讨经典型苯丙酮尿症（phenylketonuria，PKU）患儿低苯丙氨酸饮食治疗后血红蛋白及微量元素含量，了解患儿的营养状况，以便进一步完善治疗方案。【方法】采集43例经典型PKU患儿男29例，女14例，年龄5月～3岁，平均（1．78±0．65）岁]及43例正常儿童[男28例，女15例，年龄5月～3岁，平均（1．77±0．68）岁]手指末梢血，采用五通道原子吸收光谱法进行微量元素测定，同时进行血常规检测。【结果】经典型PKU患儿血锌明显低于正常对照组，血红蛋白测定差异无显著性。【结论】对低苯丙氨酸饮食治疗的经典型PKU患儿应定期进行血微量元素检测并及时补充，以纠正治疗过程中这些元素的不足，保证患儿得到全面营养，以利于其生长发育。[Objective] To investigate the blood concentration of trace element and heamoglobin（Hb） in children with classical type phenylketonuria（PKU） after low phenylalanine diet. [Methods] A total of 43 classical type PKU cases were recruited in this study, including 29 males and 14 females aged 5 months-3 years [ （ 1.78± 0.65 ） years] and treated with a low phenylalanine diet for 5 months-3 years. A group of 43 healthy children（28 males and 15 females）,aged 5 months-3 years [ （ 1.77 ± 0.68） years ] were included as a normal control. Their blood samples were analyzed for Ca, Mg, Cu,Fe,Zn,Hb et al. [Results] There were no significant differences in blood Ca,Mg,Cu,Fe, Hb between two groups, but the blood Zn in classical type PKU cases were significantly lower than that of the normal control. [Conclusions] It is indicated that blood trace element should be detected and supplemented to patients with PKU in time to ensure the full-scale nutrition in them.

关 键 词：经典型苯丙酮尿症 饮食治疗 微量元素 血红蛋白 

分 类 号：R153.2[医药卫生—营养与食品卫生学]