胃癌遗传学研究进展  

Research Progress in Genomics of the Gastric Cancer

作　　者：吕龙[1] 曹苇[2] 周晓庆[1] 

机构地区：[1]高淳县人民医院普外科,江苏高淳211300 [2]苏州大学附属第一人民医院普外科,江苏苏州225000

出　　处：《医学综述》2008年第8期1189-1191,共3页Medical Recapitulate

摘　　要：胃癌根据其组织学的差异主要分为两种,其流行病学、致病机制、基因谱和临床预后具有明显的差异。肠型胃癌发生是多因素、多步骤的过程,在肠型胃癌和癌前病变中常见的包括点突变、杂合度缺失、微卫星不稳定和高度甲基化。而在弥漫型胃癌中,往往没有癌前病变的发生,E-钙黏蛋白基因的变异和表观遗传的基因沉默可能是导致弥漫型胃癌发生的关键原因。胃癌遗传学研究的深化将有助于快速开发新的诊断技术和分子靶向治疗措施。Gastric Cancer is mainly divided into two types based on the difference in their epidemiology, pathogenesis, genetic profile and clinical outcome. The pathogenesis of intestinal-type gastric cancer follows a multistep progress. A wide range of genetic and epigenetic abnormalities including point mutation,loss of heterezygosity micresatellite instability, and hypermethylation axe described in intestinal-type gastric cancer and its precursor lesions. In contrast to the intestinal-type,diffuse-type gastric cancer is defined by a lack of precursor lesions. Mutation or epigenetic silencing of the E-cadherin gene appears to be the key carcinogenic event. A deeper understanding of the genomics of gastric cancer could lead to the rapid development of novel diagnostic techniques and molecular-based treatment strategies.

关 键 词：:胃癌 遗传学 表观遗传学 微卫星不稳定 基因甲基化 

分 类 号：R394[医药卫生—医学遗传学]