配位化合物cis-[Pd(bipy-ethyl)Cl2]的合成、晶体结构及其抗癌活性研究  

Study on Synthesis, Crystal Structure and Anticancer Activity of Complex cis-[Pd(bipy-ethyl)Cl_2]

作　　者：孙亚光[1] 谷晓夫[1] 吴琼[1] 高恩君[1] 尹洪喜[1] 任利翔[2] 

机构地区：[1]沈阳化工学院配位化学研究室,沈阳110142 [2]沈阳药科大学药学院,沈阳110016

出　　处：《无机化学学报》2008年第4期515-519,共5页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No20671064);辽宁省自然科学基金(No20052014)资助项目

摘　　要：在水热条件下,合成了配合物cis-[Pd(bipy-ethyl)Cl2],(bipy-ethyl为2,2′-联吡啶-3-甲酸乙酯)。配合物晶体属于正交晶系,Pbca空间群。配体bipy-ethyl上的2个氮原子与Pd2+螯合配位,2个氯离子为顺式端基配位,形成平面四边形配合物。配合物分子之间存在C-H…O作用,C-H…Cl作用以及Pd(Ⅱ)-氮杂芳香环作用等多种弱作用方式。通过体外活性方法测定了该配合物对人宫颈癌细胞(Hela)、人肝癌细胞(Hep-G2)和人口腔上皮癌细胞(KB)等的抑制活性,结果表明,配合物的抑制活性虽不及cis-DDP,但仍表现出较强的细胞杀伤能力。The complex cis-[Pd（bipy-ethyl）Cl2] （bipy-ethyl=2,2′-bipyridine-3-ethyl formate）was synthesized under hydrothermal conditions. X-ray crystal structure analysis was carried out to determine the crystal structure of the title complex. The crystal of the title complex belongs to orthorhombic system with space group Pbca. The Pd^2＋ ions was coordinated by two nitrogen atoms of bipy-ethyl and two terminal chlorine ions, rendering a quadrangle geometry. There are abundant C-H…Cl interaction, C-H…O interaction and Pd-Aromatic interaction between adjacent complexes. The inhibitory activity of complex with cancer cell of Hela, Hep-G2 and KB were mensurated by vitro activity methods. The result shows that although inhibitory activity of complex is not as good as cis-DDP, the complex still has strong ability to kill cancer cell.

关 键 词：配位化合物 钯(Ⅱ) 晶体结构 抗癌活性 

分 类 号：O614.823[理学—无机化学]