乳腺癌nm23-H_1等位基因缺失与肿瘤淋巴结转移相关性的研究  

Correlation between allelic deletion of nm23-H_1 and metastasis of breast carcinoma

作　　者：张丽萍[1] 袁建达[2] 张泰明[2] 许良中[2] 

机构地区：[1]上海市第六人民医院,200233 [2]上海医科大学附属肿瘤医院,200233

出　　处：《实用肿瘤杂志》1997年第6期257-259,共3页Journal of Practical Oncology

摘　　要：应用核酸分子杂交技术检测了34例乳腺癌以及相应癌旁正常乳腺组织中肿瘤转移抑制基因nm23-H1等位基因缺失情况，分析该基因的等位基因缺失与肿瘤大小，发病年龄，雌激素受体状况以及腋下淋巴结转移之间的关系。结果发现nm23-H1等位基因缺失与肿瘤大小．发病年龄以及雌激素受体状况无关．而与腋下淋巴结转移关系十分密切．有转移病例nm23-H1等位基因缺失的百分率为333％（7／21）．无转移病例等位基因缺失的百分率为77％（1／13），两组病例对比差异有显著性（P＜0．05）。研究结果提示nm23-H1基因在抑制肿瘤转移方面具有重要作用。Using Southern blot and immunohistochemical stain metheds we studied the allelic deletion of nm23-H1 gene in 34 cases ofbre3st cancer and corresponding normal breast tissues. The correlations between the allelic deletion of nm23-H1 gene and axillary lymph nede metastasis, tumor diameter. patient's age and estrogen receptor status were investigated. The results shown that eightcases of breast cancer have nm23-H1 gene allelic deletion. The nm23-H1 allelic deletion tate was 33. 3% (7/21) in axillary lymphnede metastasis grouP and 7. 7% (1/13) in the group without axillary lymph nede metastasis. There were cIose correIation be-tween allelic deletion of nm23-H1 and axillary lymph nede metastasis(P＜0. 05). No correlation between patient's age, tumor di-ameter.estrogen receptor status and the allelic deletion were found. The results suggest that nm23-H1 gene play an important rolein control the metastasis of breast cancer.

关 键 词：乳腺癌 肿瘤转移 等位基因缺失 淋巴结转移 

分 类 号：R737.902[医药卫生—肿瘤] R73－37[医药卫生—临床医学]