青紫薯色素安全性评价  

SAFETY EVALUATION OF SWEET-POTATO ANTHOCYANIN

作　　者：刘宁[1] 王春波[2] 王蜀平[3] 

机构地区：[1]青岛大学医学院图书馆,山东青岛266021 [2]青岛大学医学院药理学教研室,山东青岛266021 [3]青岛大学医学院附属医院,山东青岛266021

出　　处：《青岛大学医学院学报》2008年第2期165-167,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省教育厅资助项目(J04E17)

摘　　要：目的对青紫薯色素安全性进行评价。方法采用最大给药量试验,小鼠每天3次、每次36 mL/kg灌胃给予200 g/L的青紫薯色素水溶液14 d,观察其体质量变化和死亡情况;以仓鼠肺成纤维细胞(CHL)行染色体畸变试验,对青紫薯色素进行毒理学评价。结果小鼠灌胃给予21.6 g/(kg.d)青紫薯色素后未出现毒性反应,也无动物死亡,体质量增长良好;CHL染色体畸变试验呈阴性,染色体畸变率在正常范围内。结论青紫薯色素灌胃给药21.6 g/(kg.d)未出现急性毒性反应,青紫薯色素在1.00 g/L剂量下无致突变作用。Objective To assess the safety of sweet-potato anthocyanin. Methods The experimental mice were given 200 g/L sweet-potato anthocyanin with a dose of 36 mL/kg, three times a day, for 14 days. Body weight and death rate were recorded. The mntagenicity of sparfloxacin on CHL cell in the presence and absence of S9mix was evaluated. Results Through the whole experiment period, no significant changes in body weight and no death were observed in mice receiving sweet-potato anthocyanin, this anthocyanins did not demonstrate any effect on chromosome aberration. Conclusion Sweet-potato anthocyanin was safe and without mntagenicity action.

关 键 词：色素类 甘薯 急性毒性试验 染色体畸变 

分 类 号：R284[医药卫生—中药学]