CYP1A1、GSTM1基因多态性与肺癌遗传易感性的关系  

Relationship between susceptibility to lung cancer and genetic polymorphism in CYP1A1 and GSTM1

作　　者：刘群[1] 刘杰[1] 宋宝[1] 王哲海[1] 

机构地区：[1]山东省肿瘤医院,山东济南250117

出　　处：《山东医药》2008年第9期32-34,共3页Shandong Medical Journal

基　　金：山东省医学科学院立项项目(2006-16);山东省卫生厅资助项目(2007HW135)

摘　　要：目的探讨CYP1A1 m1、m2位点和GSTM1基因多态性与肺癌遗传易感性的关系。方法采用病例对照研究方法和寡核苷酸芯片技术对110例山东汉族肺癌患者和125例正常对照者的基因组DNA进行CYP1A1、GSTM1基因多态性分析。结果CYP1A1 m2位点、GSTM1基因型分布在肺癌组和对照组间存在统计学差异(P<0.05);携带CYP1A1 Val/Val基因型或GSTM1缺失基因型者患肺癌的危险性增高,其中吸烟个体患肺癌的风险进一步增加。结论CYP1A1 m2位点和GSTM1基因多态性可能与肺癌发生有关,吸烟与CYP1A1、GSTM1基因具有协同作用。Objective To explore the relationship between CYP1 A1, GSTM1 gene polymorphisms and genetic susceptibility to lung cancer. Methods In this study, 110 lung cancer patients and 125 age-matched healthy controls in Chinese Han nationality of Shandong were enrolled. All DNA samples from peripheral blood were genotyped for genetic polymorphisms of CYP1A1 and GSTM1 genes by oligonucleotidechip technique. Results The significant differences for distributions of CYP1A1 m2 and GSTM1 genotype were observed between lung cancer cases and healthy controls. The individuals carried CYP1A1 Val/Val or GSTM1 null genotype had an increased risk for lung cancer. There was an elevated risk for smokers in lung cancer cases having CYP1 A1 Val/Val or GSTM1 null genotype. Conclusions CYP1 A1 Val/Val and GSTM1 null genotypes may be the susceptible factors of lung cancer in Chinese Han nationality of Shandong. There may be a synergetic interaction between smoking and susceptible genotypes.

关 键 词：多态性 单核苷酸 肺肿瘤 寡核苷酸芯片 疾病遗传易感性 

分 类 号：R734.2[医药卫生—肿瘤]