HLAⅡ-DRB1等位基因与口腔扁平苔藓的相关性研究  

The study on the association between HLAⅡ-DRB1 alleles and oral lichen planus in Han population in Xinjiang

作　　者：刘奕杉[1] 王善征[2] 凌彬[1] 陈晓涛[2] 张琰[3] 钟良军[1] 

机构地区：[1]新疆医科大学第一临床医院口腔科,830054 [2]新疆医科大学第一临床医院输血科,830054 [3]新疆医科大学第一临床医院中心实验室,830054

出　　处：《实用口腔医学杂志》2008年第3期425-427,共3页Journal of Practical Stomatology

基　　金：新疆医科大学第一临床医院科研基金(编号:2004-yfy46)

摘　　要：目的:探讨人类白细胞抗原HLAⅡ-DRB1等位基因与新疆汉族口腔扁平苔藓(OLP)患者的相关性。方法:采用多聚酶链反应-序列特异性引物(PCR-SSP)技术,对34例OLP患者和123例正常对照进行HLAⅡ-DRB1等位基因表现频率检测。结果:OLP组DRB1*11等位基因表现频率(23.53%)高于正常对照组(9.76%)(P<0.05);OLP组DRB1*120x等位基因表现频率(5.88%)低于正常对照组(22.76%)(P<0.05)。结论:DRB1*11等位基因可能与新疆地区汉族人群OLP患者易感性相关;DRB1*120x等位基因可能是新疆汉族OLP患者的保护基因。Objectlve：To investigate the association of human leukocytes antigen HLAⅡ-DRB1 alleles with oral lichen planus （OLP） in Han population in Xinjiang. Methods：The allele frequency of HLAⅡ-DRB1 were detected in 34 OLP patients and 123 normal controls by polymerase chain reaction-sequence specific primers （PCR-SSP） meth- od. Results：The allele frequency of DRB1 ＊ 11 were significantly higher （23.53% vs 9.76 % ） , however, DRB1 ＊ 120x were substantially lower （5.88% vs 22.76% ） in OLP group than that in normal controls （P 〈0.05）. Conclusion：DRB1 ＊ 11 alleles can be the susceptible genes for OLP, however, DRB1 ＊ 120x alleles may be the protective gene for OLP in Han population in Xinjiang.

关 键 词：口腔 扁平苔藓 人类白细胞抗原HLA—DRB1 等位基因 

分 类 号：R781.5[医药卫生—口腔医学]