茯苓聚糖的氚离子束标记及其在小鼠体内的药物动力学研究  

Ion beam tritium labelling of pachyman and its pharmacokinetics study in mice

作　　者：谢炳华[1] 张年宝[1] 俞斌伟[1] 秦锐芳[1] 要福增[1] 戴荣兴[2] 方军[2] 黄坚[2] 

机构地区：[1]中国科学院上海原子核研究所 [2]上海中医学院

出　　处：《核技术》1990年第11期693-695,共3页Nuclear Techniques

摘　　要：本文采用氚离子束标记法,对茯苓聚糖进行了标记,放射性比活性达1.81—2.07TBq/mmol。药物动力学研究证明~3H-茯苓聚糖尿素液口服灌喂小白鼠,按一定时间在尾部静脉取血样作放射性分析。得到的药-时曲线适合于双定模型。In this paper, we discribe technique--Ion beam tritium labelling method for thepreparation of tritium compounds and its use in the tritiation of pachyman. After removal of readlylabile tritium, the tritiated product was obtained with a specific radioactivity of (1.81-2.07TBq/mmol).The pharmacokinetics study was done in mice using 3H-pachyman urea solution. The blood concentration - time curve obtained after p. o. of 3H-pachyman was shown to fit a two compartment open model.

关 键 词：^(3)H-茯苓聚糖 氚离子束标记法 药物动力学 

分 类 号：R914[医药卫生—药物化学]