法莫替丁粉针剂与注射液治疗消化性溃疡合并出血的比较  

Famotidine for injectable powder vs injection in treating peptic ulcer hemorrhage

作　　者：吴国亭[1] 徐凯建[1] 郭晓军[1] 白秀萍[1] 宋钦辉[1] 

机构地区：[1]哈尔滨医科大学临床药理基地

出　　处：《新药与临床》1997年第6期329-330,共2页

摘　　要：目的：比较法莫替丁粉针剂与注射液治疗消化性溃疡合并出血的疗效和安全性。方法：法莫替丁粉针组１００例（Ａ组）给该粉针剂２０ｍｇ加入０．９％氯化钠注射液２０ｍＬ，ｂｉｄ，ｉｖ；法莫替丁注射液组５０例（Ｂ组）给法莫替丁葡萄糖注射液２５０ｍＬ（含法莫替丁２０ｍｇ），ｂｉｄ，ｉｖ，ｇｔ，疗程均为４ｗｋ。结果：Ａ和Ｂ组止血效果分别为８９％和８４％，（Ｐ＞０．０５）；５ｄ内上腹部疼痛缓解率分别为８５％和８２％，（Ｐ＞０．０５）。２组疗效综合评价分别为８７％和８４％（Ｐ＞０．０５）；不良反应发生率分别是２２％和２８％，（Ｐ＞０．０５）。结论：粉针剂与注射液的疗效和安全性相似。AIM: To compare the efficacy and safety of famotidine for injectable powder (FIP) and injection of famotidine (FI) in treating peptic ulcer hemorrhage. METHODS: The 100 patients were treated FIP 20 mg, in 0.9% sodium chloride 20 mL, iv, bid (group A), while 50 patients were given famotidine in glucose injection 250 mL (include the famotidine 20 mg) iv gtt, bid (group B), for 4 wk. RESULTS: Bleeding was stopped in 89% and 84% of patients in group A and group B, respectively (P>0.05). Pain relieve rates within 5 d were 85% and 82%, respectively (P>0.05). The general evaluation of efficacy rates in 2 groups were 87% and 84%, respectively (P>0.05). The incidences of adverse reactions were 22% and 28%, respectively (P>0.05). CONCLUSION: FIP showed a similar efficacy and adverse reactions with FI in the treatment of patients with peptic ulcer hemorrhage.

关 键 词：消化性溃疡 出血 并发症 法莫替丁 粉针剂 

分 类 号：R573.105[医药卫生—消化系统] R975.6[医药卫生—内科学]