华佗健聪汤对Aβ所致老年痴呆大鼠功能改善及相关机理的研究(1)--行为学观察及评价  

The Improvement of Function and Its Relative Mechanism of Huatuo Jiancong Tang on Rats with Aβ Induced Alzheimer's Disease (1)——The Behavior Observation and Evaluation

作　　者：江励华[1] 段金廒[1] 崔明超[1] 袁晓琳[1] 林靓[2] 王明艳[1] 陆平成[1] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]安徽中医药高等专科学校,安徽芜湖241000

出　　处：《中华中医药学刊》2008年第6期1234-1236,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省高校研究生科技创新计划项目(2006-131)

摘　　要：目的:探讨华佗健聪汤对Aβ所致老年痴呆的大鼠行为学变化的改善作用。方法:用凝聚态Aβ1-42定向注射22月龄SD大鼠右侧海马CA1区制备出AD动物模型,分别观察正常组、假损伤组、模型组、中药预防组、中药治疗组、阳性药物对照组各组大鼠的一般状态及记录定位航行实验的游泳时间,比较各组之间的差异。结果:中药预防组和治疗组大鼠一般状态明显好于模型组,定位航行时间亦比模型组大为缩短,尤其是预防组大鼠,在测试其学习能力的定位航行时间Ⅱ时,表现非常突出,成绩优于正常组。结论:本方对Aβ所致老年痴呆的大鼠有显著的益智作用,其预防性意义尤为突出。Objective： To study the Effect of Huatuo Jiancong Tang on Rats with AβInduced Alzheimer ＇s Disease about the behavior improvement（ mainly on memory and study function）. Methods： Inject condensed Aβ1 -42 into the hippocampus of 22months- rats to make animal model. Observe the general condition of rats of ordinary group, model group, traditional Chinese Medicine - prevention group, traditional Chinese Medicine - treatment group and positive control - group, and record the swimming time of marginal division test respectively. Results ： The general state of traditional Chinese Medicine prevention group, traditional Chinese Medicine treatment group is superior to the model group obviously, and the time of marginal division is shorter than the model group. Especially when testing the study ability from the time II of marginal division , the traditional Chinese Medicine prevention group presented prominently, better than the normal group on marks. Conclusion ： This prescription promote the intelligence of rats obviously and the prevention function is prominent.

关 键 词：华佗健聪汤 AΒ 老年痴呆 行为学 定位航行时间 

分 类 号：R-33[医药卫生]