置入铜丝缠绕型支架制作猪急性心肌梗死模型  

Replication of Acute Myocardial Infarction by Implantating Copper-stent in Coronary Artery of Pig

作　　者：赵慧强[1] 韩雅玲[1] 王守力[1] 崔继福[1] 王斌[1] 荆全民[1] 马颖艳[1] 栾波[1] 

机构地区：[1]中国人民解放军沈阳军区总医院全军心血管病研究所心内科,辽宁省沈阳市110016

出　　处：《中国动脉硬化杂志》2008年第3期189-192,共4页Chinese Journal of Arteriosclerosis

基　　金：辽宁省科技攻关计划项目(2007225004-8)

摘　　要：目的探讨在猪冠状动脉内置入铜丝缠绕型支架制作急性心肌梗死模型的可行性,建立一种新的急性心肌梗死模型方法。方法16头中国实验用小型猪经股动脉穿刺,在前降支置入自制的铜丝缠绕型支架。1周内观察心肌肌钙蛋白I、心电图、心脏超声和冠状动脉造影。然后处死取出心脏,取目标冠状动脉和心肌,做病理学检查。结果16头小型猪均发生了心肌梗死。梗死发生后死亡2头,其中1头在术后8 h猝死,1头在术后1周冠状动脉造影复查时死于麻醉中;其余14头均存活在1周以上,完成复查,总的成功率为87.5%。结论该模型制作具有操作简单、创伤小、成本低、死亡率低、成功率高等诸多优点,可作为较好的实验研究动物模型。Aim To explore and estabhsh a new pig model of acute myocardial infarction. Methods Serf-made copper-stents were implanted in left anterior deseending coronary arteries of 16 pigs. Troponin Ⅰ, echocardiography, coronary angiography, electrocardiogram and pathologic evaluation were performed to confirm AMI at one week after procedure. Results The model of myocardial infarction was successfully established in 14 of the 16 pigs and the success rate was 87.5% （ 14/16 ）. One pig had sudden death at 8 hours and another died during anaestliesia at one week after procedure. Conclusion The method of establishing the pig model of myocardial infarction by implanting eopper-stent in coronary artery is simple, convenient, safe and has a relatively high success rate and low mortality.

关 键 词：病理学与病理生理学 急性心肌梗死 冠状动脉 支架 动物模型 

分 类 号：R363[医药卫生—病理学]