抗骨质疏松药雷尼酸锶的合成  

Synthesis of Strontium Ranelate,an Antiosteoporosis Drug

作　　者：丁翔宇[1] 蒋晔[1] 贾湘曼[1] 刘丰华[1] 

机构地区：[1]华河北医科大学药学院,石家庄050017

出　　处：《中国药学杂志》2008年第11期874-876,共3页Chinese Pharmaceutical Journal

摘　　要：目的研究雷尼酸锶的化学合成。方法以枸橼酸为起始原料,经过脱羧、酯化、环合、烷基化、水解成盐等多步反应生成终产物雷尼酸锶。结果雷尼酸锶的结构经IR,1H-NMR,13C-NMR得到证实,总产率约为42.6%。结论本合成路线操作简单、成本低,适合工业化生产。OBJECTIVE To study the synthesis route of strontium ranelate, an antiosteoporosis drug. METHODS Strontium ranelate was synthesized from citric acid via decarboxylation, esterification, cyclization, alkylation, hydrolysis and salification. RESULTS The structure of strontium ranelate was confirmed by IR, ^1H-NMR, ^13C-NMR, the total yield was 42.6% approximately. CONCLUSION The synthesis route was simple, low cost and could be used in industry.

关 键 词：雷尼酸锶 合成 骨质疏松 

分 类 号：R914[医药卫生—药物化学]