Glial involvement in trigeminal central sensitization  

作　　者：Yu-feng XIE 

机构地区：[1]Department of Physiology and Pathophysiology, Xi'an Jiaotong University, Xi 'an 710061, China [2]Department of Oral Physiology, University oJ Toronto, Toronto, Canada M5G 1G6

出　　处：《Acta Pharmacologica Sinica》2008年第6期641-645,共5页中国药理学报（英文版）

摘　　要：Recent studies have indicated that trigeminal neurons exhibit central sensitization, an increase in the excitability of neurons within the central nervous system to the extent that a normally innocuous stimulus begins to produce pain after inflammation or injury, and that glial activities play a vital role in this central sensitization. The involvement of glial cells in trigeminal central sensitization contains multiple mechanisms, including interaction with glutamatergic and purinergic receptors. A better understanding of the trigeminal central sensitization mediated by glial cells will help to find potential therapeutic targets and lead to developing new analgesics for orofacial-specific pain with higher efficiency and fewer side-effects.Recent studies have indicated that trigeminal neurons exhibit central sensitization, an increase in the excitability of neurons within the central nervous system to the extent that a normally innocuous stimulus begins to produce pain after inflammation or injury, and that glial activities play a vital role in this central sensitization. The involvement of glial cells in trigeminal central sensitization contains multiple mechanisms, including interaction with glutamatergic and purinergic receptors. A better understanding of the trigeminal central sensitization mediated by glial cells will help to find potential therapeutic targets and lead to developing new analgesics for orofacial-specific pain with higher efficiency and fewer side-effects.

关 键 词：GLIA TRIGEMINAL central sensitization 

分 类 号：R971[医药卫生—药品]