National Natural Science Foundation of China(82170971,82373187and 82002888);Fundamental Research Funds for the Central Universities(YJ201987);Sichuan Science and Technology Program(2021ZYD0090 and 2022YFS0207);Scientific Research Foundation,West China Hospital of Stomatology Sichuan University(QDJF2019-3 and RD-03-202110);CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-004)。
Oral squamous cell carcinoma(OSCC)associated pain commonly predicts adverse events among patients.This clinical feature indicates the engagement of nociceptors on sensory neurons during the development of malignancy.H...
supported by the National Natural Science Foundation of China(81771195 and 81971061);the Program for Innovative Research Team in Universities of Henan Province(22IRTSTHN028).
Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans;however,the underlying mechanisms remain largely unknown.In this study,we investigated the possible contribution of interaction b...
Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory perception.It is unclear whether trigeminal sensitivity is similar across...
Dental primary afferent(DPA)neurons and proprioceptive mesencephalic trigeminal nucleus(MTN)neurons,located in the trigeminal ganglion and the brainstem,respectively,are essential for controlling masticatory functions...
supported by the National Natural Sclence Foundation of China in 2021;No.82171213;the Natural Science Foundation of Fujian Province in 2019;No.2019J01289 (both to DSL)
The trigeminal root entry zone is the zone at which the myelination switches from peripheral Schwann cells to central oligodendrocytes.Its special anatomical and physiological structure renders it susceptible to nerve...
BACKGROUND Primary trigeminal neuralgia can achieve satisfactory results through clinical treatment and intervention.The pathogenesis of neuralgia caused by varicellazoster virus infection of the trigeminal nerve is m...
Microvascular compression on the trigeminal root entry zone(TREZ)is the main aetiology of trigeminal neuralgia(TN)patients.To investigate brain-derived neurotrophie factor(BDNF)and glial cell line derived neurotrophic...
Schwann cells are generally considered to play an important role in nerve repair and have been previously associated with neuropathic pain promoting the formation of the myelin sheath and the direct regeneration of ax...
the National Natural Science Foundation of China(31970938,31671091,31871064,81571070,and 31700899);the Natural Science Research Program of Jiangsu Province,China(BK20171255 and BK20191448);the Qing Lan Project;the Innovation and Entrepreneurship Training Program for College Students in Jiangsu Province,China(201810304029Z)。
Trigeminal neuropathic pain(TNP)is a significant health problem but the involved mechanism has not been completely elucidated.Toll-like receptors(TLRs)have recently been demonstrated to be expressed in the dorsal root...
The ability to perceive and respond to diverse noxious environmental stimuli,such as temperature(heat,cold),mechanical force(pinprick,pinch),and chemicals,is essential for keeping animals and humans away from damage.T...