Comparison of trigeminal lateralization with differing stimulants  

作　　者：Tiffany Chen Nicolas S.Poupore Michael C.Shih Thomas S.Edwards Shaun A.Nguyen Zachary M.Soler Rodney J.Schlosser 

机构地区：[1]Department of Otolaryngology‐Head and Neck Surgery,Medical University of South Carolina,Charleston,South Carolina,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第1期66-69,共4页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory perception.It is unclear whether trigeminal sensitivity is similar across different transient receptor potential(TRP)receptors or if dysfunction of different receptors results in differing patient symptoms.Therefore,a prospective cohort study was conducted,consisting of trigeminal lateralization testing with three different stimulants(eucalyptol,isothiocyanate,acetic acid),olfaction testing with Sniffin'Sticks,and measurement of various patient‐reported outcome measures(PROMs).A total of 50 participants were enrolled across the olfactory spectrum.Mean TDI score was 27.1±8.3(range 7.0–39.5)with 38%normosmic and 62%dysosmic.Mean trigeminal lateralization scores out of 20 in the overall cohort were 16.18(2.78)for eucalyptol,14.94(3.49)for mustard oil,and 15.28(3.68)for vinegar.Eucalyptol showed a significant correlation with threshold scores of Sniffin'Sticks.A significant correlation was found between acetic acid and various PROMs.None of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to age.The lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other receptors.Additional investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings.

关 键 词：CHEMOSENSORY OLFACTION TRIGEMINAL TRP receptor 

分 类 号：R745.11[医药卫生—神经病学与精神病学]