The expresion of BDNF and GDNF in the trigeminal root entry zone and trigeminal ganglion neurons in trigeminal neuralgia animal model  

作　　者：Luo Daoshu Luo Lili Lin Ren 

机构地区：[1]Department of Human Anatomy,School of Basic Medical Sciences,Fujian Medical University,Fuzhou 350122

出　　处：《解剖学杂志》2021年第S01期120-120,共1页Chinese Journal of Anatomy

摘　　要：Microvascular compression on the trigeminal root entry zone(TREZ)is the main aetiology of trigeminal neuralgia(TN)patients.To investigate brain-derived neurotrophie factor(BDNF)and glial cell line derived neurotrophic factor(GDNF)in the trigeminal ganglion(TG)and TREZ,immunofluorescence staining and Western blot were used in a rat TN model.Both BDNF and GDNF were observed in the TG neurons and TREZ.The BDNF dimer in the TG increased in the TN group while the GDNF decreased after compression injury.The ratio of BDNF dimer/pro-BDNF in the TREZ of the TN group was higher than that in the sham group,but the GDNF in the TREZ was.

关 键 词：TRIGEMINAL NEURALGIA GDNF 

分 类 号：R74[医药卫生—神经病学与精神病学]