血管紧张素原基因多态性与血管性认知障碍关系的研究  

Relationship between angiotensinogen gene polymorphism and vascular cognitive impairment

作　　者：杨凌[1] 赤克美[2] 刘小超[1] 尚军[1] 余华峰[2] 

机构地区：[1]首都医科大学附属北京同仁医院中心实验室,北京100730 [2]首都医科大学附属北京同仁医院神经内科,北京100730

出　　处：《中国综合临床》2008年第7期671-674,共4页Clinical Medicine of China

摘　　要：目的探讨血管紧张素原（AGT）基因G-6A和M235T多态性与血管性认知障碍（VCI）的关系。方法采用随机对照研究，聚合酶链反应（PCR）方法检测VCI组（67例）、正常对照组（71例）AGT基因G-6A和M235T多态性。结果VCI组AGT基因M235T T等位基因频率0.73，TT基因型频率0．52，与对照组（0．68，0．45）比较差异无统计学意义（P〉0．05），TT基因型对VCI的比数比为0．544（95％CI为0．208-1．424。P〉0．05）。VCI组AGT基因G-6A等位基因频率0，69，AA基因型频率0，48，与对照组（0．63，0．39）比较差异无统计学意义（P〉0．05），AA基因型对VCI的比数比为0．602（95％CI为0．252～1.738，P〉0.05）。结论脑梗死伴血管性认知障碍患者与AGT基因G-6A和M235T多态性无关，AGT基因这两个位点多态性未参与发病。Objective To investigate the relationship between vascular cognitive impairment （ VCI ） and the angiotensinogen（AGT） gene （G-6A and M235T） polymorphism. Methods Randomnized controled study was applied in the study. AGT gene G-6A and M235T genotypes of 67 cases with VCI and 71 normal controls were determined by polymerase chain reaction （ PCR）. Results For the location of M235T, the frequencies of T allele（ 0.73 ） and TT genotype （ 0.52 ） were observed in VCI compared with control group （ 0.68,0.45, P 〉 0.05 ）. The odds ratio associated with TT/MM genotype was 0.544 （95% CI 0. 208 - 1. 424,P 〉 0.05）. For the location of G-6A, the frequencies of A allele（0.69） and AA genotype （0.48） were observed in VCI compared with control subjects （0.63, 0.39, P 〉 0.05 ）. The odds ratio associated with AA/GG genotype was 0. 602 （95 % CI 0. 252 - 1. 738, P 〉 0.05 ）. There was no difference in allele distribution between 67 VCI patients and the controls. Conclusion There is no correlation between vascular cognitive impairment and AGT gene polymorphisms of M235T and G-6A. AGT gene polymorphism is not included in the risk factors for development vascular cognitive impairment.

关 键 词：血管性认知障碍 血管紧张素原 基因多态性 

分 类 号：R749.13[医药卫生—神经病学与精神病学]