吡罗昔康-β-环糊精包合物的制备研究  

Preparation of Inclusion Complex of Piroxicam with β-Cyclodextrin

作　　者：陈寅生[1] 陈洪轩[1] 马莉 

机构地区：[1]河南大学药学院,河南开封475004

出　　处：《中国药业》2008年第15期49-50,共2页China Pharmaceuticals

摘　　要：目的将吡罗昔康与β-环糊精制备成包合物,降低其对胃肠道的刺激性。方法采用饱和水溶液法,以收率和包合率为指标,用正交试验设计法筛选最佳包合条件,然后用显微镜法和X-射线衍射法分别对制备的包合物进行鉴定。结果最佳包合条件是吡罗昔康与β-环糊精的物质的量比为1:2.5,包合温度50℃,包合时间6h,搅拌速度600r/min;经显微镜法和X-射线衍射法鉴定,形成了吡罗昔康-β-环糊精包合物。结论用饱和水溶液法制备吡罗昔康-β-环糊精包合物,收率和包合率都较高,且操作方法简单易行。Objective To prepare an inclusion complex of piroxicam （PIR） with β-cyclodextrin （β-CD） for reducing the gastrointestinal tract irritation of PIR. Methods The study was carried out using orthogonal design. The recovery and inclusion rate of inclusion complex were used as the criteria of selecting the optimum preparation condition. The inclusion complex was identified by microscopy and X- ray diffraction. Results The optimum preparation conditions for inclusion were established as follows： the mol ratio of PIR and β- CD was 1 ： 2.5, temperature 50 ℃, time 6 h and rotate speed 600 r/min. The formation of inclusion complex of PIR- β- CD was confirmed by microscopy and X- ray diffraction. Conclusion Using saturated solution method to prepare the inclusion complex of PIR- β- CD can have a preferable recovery and inclusion rate with simplified operation.

关 键 词：吡罗昔康 Β-环糊精 饱和水溶液法 正交试验设计 X-射线衍射法 

分 类 号：TQ460.6[化学工程—制药化工] R971.1[医药卫生—药品]