CPT-11联合草酸铂、5-Fu方案二、三线治疗晚期大肠癌的临床研究  

A Combination of CPT-11,Oxaliplatin and 5-Fu as a Second or Third Line Treatment for Advanced Colorectal Cancer

作　　者：沈康[1] 黄新恩[1] 戴爱娣[1] 钱芝英[1] 孙蔚莉[1] 

机构地区：[1]江苏省肿瘤医院化疗科

出　　处：《肿瘤基础与临床》2008年第4期340-342,共3页journal of basic and clinical oncology

基　　金：2005年江苏省人事厅"六大人才高峰"项目;江苏省科技发展计划项目(编号:BS2006006);2007年江苏省卫生厅"333高层次人才培养工程"项目

摘　　要：目的观察CPT-11联合草酸铂、5-Fu作为二、三线方案治疗晚期大肠癌的近期疗效及毒副反应。方法12例晚期大肠癌,均于2006年10月至2008年3月在江苏省肿瘤医院化疗科接受二、三线化疗。具体方案为草酸铂85 mg/m2,iv gtt,d1,8,15;5-Fu 600mg/m2,iv gtt d1-5;CPT-11 60 mg/m2,iv gtt,d2,9,16。28 d为1周期,2个周期后评估疗效及毒副反应。结果可评价疗效12例,其中PR 3例,SD 6例,PD 3例,有效率25%,临床获益率75%。主要毒副反应为恶心、呕吐、迟发性腹泻、肝脏损害、神经毒性和骨髓抑制等。结论CPT-11联合草酸铂、5-Fu方案二、三线治疗晚期大肠癌有较好的疗效,且毒副反应可以耐受。Objective To investigate the efficacy and safety of CPT-11 combined with oxaliplatin and 5-Fu as second or third line treatment for advanced colorectal cancer patients. Methods From October 2006 to March 2008, 12 patients of Jiangsu Tumor Hospital ＆ Research Institute with pathologically confirmed advanced colorectal cancer entered into this study. Chemotherapy regimen contained oxaliplatin 85 mg/m^2 , iv gtt, d1,8,15 5-Fu 600 mg/m^2 , iv gtt d1-5 ; CPT-11 60 mg/m^2 , iv gtt, d2,9,16 , every 4 weeks as a cycle. Assessment on efficacy and toxicity was conducted after two cycles. Results After two cycles of treatment, 3 patients achieved partial remission, 6 with stable and 3 with progressed disease. Thus, response rate was 25% （3/12）, clinical benefit rate was 75% （9/12）. Major toxicities included nausea, vomiting, delayed diarrhea, liver damage, neurological toxicity and myelosuppression, etc. Conclusion The combination of CPT-11, oxaliplatin and 5-Fu as a second or third line chemotherapy for advanced colorectal cancer has rational efficacy and is well tolerated.

关 键 词：晚期大肠癌 CPT-11 草酸铂 5-FU 

分 类 号：R730.53[医药卫生—肿瘤] R735.34[医药卫生—临床医学]