UGT2B17基因的缺失多态性与鼻咽癌危险性的关系  

Correlation of Deletion Polymorphism of UGT2B17 Gene with Risk of Nasopharyngeal Carcinoma

作　　者：徐金芬[1] 李大疆[1] 潘清华[1] 张如华[1] 陈丽珍[1] 冯启胜[1] 曾益新[1] 贾卫华[1] 

机构地区：[1]华南肿瘤学国家重点实验室∥中山大学肿瘤防治中心实验研究部,广东广州510060

出　　处：《中山大学学报（医学科学版）》2008年第4期490-494,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国际科技合作重点项目(2004DFA05700)

摘　　要：【目的】探讨UGT2B17基因的缺失多态性与鼻咽癌发病的相关关系。【方法】利用基因特异性引物扩增的方法鉴定不同人群UGT2B17基因的缺失多态性,研究对象包括鼻咽癌高发区广东地区的170例鼻咽癌患者(96例血标本和74例组织标本)和96例健康对照(血标本),鼻咽癌低发区河南及山西的各96例健康对照(血标本),观察UGT2B17基因的缺失多态性在中国鼻咽癌高发区和低发区人群之间的差异,并通过在鼻咽癌高发区广东进行的病例对照研究,运用二分类logistic回归分析研究UGT2B17基因的缺失多态性与鼻咽癌危险性的相关关系。【结果】①UGT2B17基因的纯合缺失型(del/del)在中国不同地区人群中的分布频率均较高(广东健康人群,67.5%;广东鼻咽癌患者,62.9%;河南健康人群,58.2%;山西健康人群,66.3%),且相互之间没有显著性差异(P>0.05),但其远远高于非洲和高加索人群(约10%)。②UGT2B17的各基因型和鼻咽癌之间的危险性分析结果显示UGT2B17基因的各基因型均不会增加鼻咽癌发病的危险性(del/ins:OR=1.693,95%CI=0.636～4.503;del/del:OR=1.132,95%CI=0.490～2.616;del/del+del/ins:OR=1.253,95%CI=0.551～2.847)。【结论】①UGT2B17基因的缺失多态性可能与种族密切相关,②UGT2B17基因的缺失多态性与鼻咽癌的发病未见显著关联。[Objective] To investigate the relationship of deletion polymorphism of UGT2B17 with risk of nasopharyngeal carcinoma （NPC）. [Methods] Using gene-specific primers amplification method to explore the deletion polymorphism of UGT2B17 among different groups, including 170 Guangdong NPC patients （96 blood samples and 74 biopsy samples）, 96 healthy Cantonese and 96 healthy volunteers from Henan as well as 96 from Shanxi respectively （blood samples）. The frequency of UGT2B17 deletion polymorphism in genomic DNA was compared among each groups. Meanwhile, conditional logistic regression was used to analyze the relationship between the deletion polymorphism of UGT2B17 and NPC. [Results] ①The frequency of UGT2B17 homozygous deletion genotype （del/del） is high （Guangdong healthy,67.5% ;Guangdong NPC,62.9% ; Henan healthy, 58.2% ; Shanxi heahhy,66.3%）and has no significant difference among people from different areas in China, but it is higher than people in Africa or Caucasus （about 10%）. ② The risk estimation shows that none of the UGT2B17 genotype can increase the risk of NPC （del/ins ： OR=1.693, 95%CI= 0.636-4.503 ; del/del ： OR= 1.132, 95%CI= 0.490-2.616; del/del＋del/ins：OR=1.253; 95%CI=0.551-2.847）. [Conclusion] ①There may be a close relationship between race and the deletion polymorphism of UGT2B17. ②There is no significant association between deletion polymorphism of UGT2B17 and risk of NPC.

关 键 词：鼻咽癌 UGT2817基因/遗传学 缺失多态性 

分 类 号：R739.7[医药卫生—肿瘤]