PTEN： a default gate-keeping tumor suppressor with a versatile tail  

作　　者：Xinjiang Wang Xuejun Jiang 

机构地区：[1]Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA

出　　处：《Cell Research》2008年第8期807-816,共10页细胞研究（英文版）

摘　　要：The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In this review, we briefly discuss recent advances concerning PTEN regulation and how such knowledge facilitates our understanding and further exploration of PTEN biology. The carboxyl-tail of PTEN, which appears to be associated with multiple types of posttranslational regulation, will be under detailed scrutiny. Further, a comparative analysis of PTEN and p53 suggests while p53 needs to be activated to suppress tumorigenesis （a dormant gatekeeper）, PTEN is probably a constitutive surveillant against cancer development, thus a default gatekeeper.

关 键 词：PTEN tumor suppressor posttranslational regulation UBIQUITINATION p53 

分 类 号：R394[医药卫生—医学遗传学]