3′-大豆苷元磺酸钠的体外抗氧化研究  

In vitro Antioxidant Properties of 3′-Daidzein Sulfonate Sodium

作　　者：师梅梅[1] 杨建雄[1] 张改平[1] 张尊听[2] 

机构地区：[1]陕西师范大学生命科学学院 [2]陕西师范大学化学与材料科学学院,西安710062

出　　处：《天然产物研究与开发》2008年第4期698-700,680,共4页Natural Product Research and Development

基　　金：国家自然科学基金(20175012)

摘　　要：为研究3′-大豆苷元磺酸钠(DSS)的体外抗氧化活性,测定了DSS对超氧自由基(O2-.)、羟基自由基(.OH)和1,1-二苯基-2-苦苯肼自由基(DPPH.)的清除能力,及其对Fe2+诱导的脂质过氧化反应和β-胡萝卜素/亚油酸自氧化体系的抑制作用。结果表明,DSS对DPPH.有一定的清除能力,对超氧自由基的清除能力较强,能很好地清除.OH自由基,对脂质过氧化有一定的抑制作用,对β-胡萝卜素/亚油酸自氧化体系有明显的抑制作用。说明DSS的药理作用可能与其较强的抗氧化能力有关。The antioxidant activity of the 3′-daidzein sulfonate sodium （DSS） was investigated by employing several in vitro assay systems, including 1,1-diphenyl-2-picrylhydrazyl （ DPPH · ）/peroxide anion/hydroxyl radical-scavenging, peroxidation of polyunsaturated fatty acid from yolk lipoprotein induced by Fe^2 ＋ method, and β-carotene/linoleic acid assay system. DSS showed scavenging activity against free radicals such as DPPH · , peroxide anion and hydroxyl radicals. Furthermore, DSS exhibited powerful inhibitory effects on peroxidation of polyunsaturated fatty acid from yolk lipoprotein induced by Fe^2＋ and notable inhibitory effects on β-earotene/linoleie acid assay system at all the tested concentration levels. The results suggested that the biological functions of DSS might correlate with its powerful antioxidant activity.

关 键 词：3′-大豆苷元磺酸钠 体外抗氧化 超氧自由基 羟自由基 DPPH· 

分 类 号：R151.2[医药卫生—营养与食品卫生学] Q946.8[医药卫生—公共卫生与预防医学]