帕罗西汀与文拉法辛治疗广泛性焦虑的对照研究  

Comparative study of paroxetine and venlafaxine in the treatment of generalized anxiety disorder

作　　者：史青[1] 张兆翠[1] 陈红生[1] 王谦文[1] 

机构地区：[1]山东省滨州市人民医院精神卫生中心,山东滨州256610

出　　处：《中国民康医学》2008年第17期1962-1963,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:比较帕罗西汀与文拉法辛治疗广泛性焦虑的疗效及安全性。方法:将60例广泛性焦虑患者随机分为两组,分别给予帕罗西汀与文拉法辛治疗,疗程6周,用汉密尔顿焦虑量表(HAMA)和焦虑自评量表(SAS)在治疗前及治疗1、2、4、6周评定疗效,用副反应量表(TESS)评定不良反应。结果:帕罗西汀组有效率83.3%,文拉法辛组有效率80.0%,两组总体疗效相仿,文拉法辛起效较快。两组不良反应均较轻,安全性好。结论:帕罗西汀和文拉法辛抗焦虑疗效肯定,不良反应少,文拉法辛起效较快。Objective：To compare the efficacy and side effects of paroxetine and venlafaxine in the treatment generalized anxiety disorder. Methods： Sixty patients with generalized anxiety disorder were randomly assigned into paroxitine groups and venlafaxine groups for six weeks, and measured with Hamilton anxiety scale （HAMA）and Self- Rating Anxiety Scale（SAS） before treatment and 1,2,4,6 weeks after treatment. Safety was evaluated by treatment emergent symptom scale（TESS）. Results： The significant improve- ment rate of paraxetine groups was 83.3% and venlafaxine groups was 80.0%. The both drugs were similar in efficacy. Side effects of both drugs were less. Scores of HAMA was significantly lower in venlafaxine group than those in paroxetine group in 1,2,4,6 weeks after treatment. （P 〈 0.05 ）. Conclusions： Paroxetine and venlafaxine are both effective and safe drug in the treatment of generalized anxiety disorder. Venlafaxine takes effect rapidly.

关 键 词：帕罗西汀 文拉法辛 广泛性焦虑 

分 类 号：R749.72[医药卫生—神经病学与精神病学]