炎症性肠病遗传易感性的研究进展  

Recent advances in the genetic predisposition of inflammatory bowel disease

作　　者：李媚[1] 高翔[2] 胡品津[2] 

机构地区：[1]中山大学附属第一医院黄埔院区消化内科,广东广州510700 [2]中山大学附属第一医院消化内科,广东广州510080

出　　处：《国际内科学杂志》2008年第8期493-496,F0003,共5页International Journal of Internal Medicine

摘　　要：炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),近年来发病呈上升趋势。IBD的发病机制尚不明确,越来越多的证据表明遗传易感性在IBD的发病中起重要作用,本文概述近年关于IBD遗传易感性的研究进展,主要讨论近年报道较多的被认为与IBD有关的几个易感基因。Inflammatory bowel disease （IBD） is a chronic inflammatory condition of the gastrointestinal tract and consists of Crohn＇s disease （CD） and ulcerative colitis （UC）. The morbidity of IBD has increased in recent years while the precise etiology of this disease remains unknown. More and more studies have shown that genetic susceptibility plays a key role in the development of IBD. To better understand the etiology of IBD, this article reviewed the recent advances in studies on genetic susceptibility of IBD and focused on the susceptibility genes which were thought to be associated with IBD.

关 键 词：炎症性肠病 克罗恩病 溃疡性结肠炎 疾病遗传易感性 

分 类 号：R574[医药卫生—消化系统]