44例儿童青少年鼻咽癌临床和预后分析  

Clinical and prognostic analysis of nasopharyngeal carcinoma in 44 children and adolescents

作　　者：洪继东[1] 廖遇平[1] 袁君[1] 魏瑞[1] 王学伟[1] 毛海娇[1] 

机构地区：[1]中南大学湘雅医院肿瘤科,长沙410008

出　　处：《中南大学学报（医学版）》2008年第8期723-726,共4页Journal of Central South University ：Medical Science

摘　　要：目的:分析儿童青少年鼻咽癌临床特点、疗效和预后因素。方法:1987年6月至2003年12月收治儿童青少年鼻咽癌44例,均行放射治疗,部分行辅助化疗。Kaplan-Meier法用于生存分析和单因素分析,Cox模型进行多因素分析。结果:3年、5年生存率分别为84.2%和62.3%,单因素分析表明临床分期、淋巴结(lymphnode,N)分期、放射剂量、化疗是影响预后的因素,多因素分析显示N分期、化疗是影响预后的独立因素。结论:儿童青少年鼻咽癌就诊时多属中晚期,易出现远处转移,宜采用综合治疗提高疗效。Objective To evaluate the clinical effect and prognostic factors of nasopharyngeal carcinoma in 44 children and adolescents. Methods From June 1987 to December 2003,44 children and adolescents with nasopharyngeal carcinoma were treated by radiotherapy, and some patients also received chemotherapy. Kaplan-Meier method was used for the survival rate and univariate analysis, and Cox proportional hazard model was used in multivariate analysis. Results The 3,5 year survival rate was 84. 2% and 62. 3%. In the univariate analysis,clinical stage, lymph node（N） stage, radiotherapy dose and chemotherapy were significant prognostic factors of survival. In the multivariate analysis, N stage and chemotherapy were the prognostic factors in the survival rate. Conclusion Most nasopharyngeal carcinomas belong to the advanced degree. These patients are sensitive to radiotherapy and chemotherapy. Combined modality therapy can improve the clinical effect of nasopharyngeal carcinoma in children and adolescents.

关 键 词：鼻咽癌 预后 儿童 青少年 综合治疗 

分 类 号：R739.63[医药卫生—肿瘤]