fascin蛋白在经典型霍奇金淋巴瘤R-S细胞中的表达及其意义  

Expression and significance of fascin of R-S cells in classical Hodgkin lymphoma

作　　者：刘真喜[1] 余力[1] 欧阳小明[2] 

机构地区：[1]南方医科大学珠江医院病理科,广东510282 [2]广州医学院附属第二医院病理科,广东510260

出　　处：《重庆医学》2008年第16期1789-1790,1799,共3页Chongqing medicine

摘　　要：目的探讨经典型霍奇金淋巴瘤(CHL)R-S细胞中fascin蛋白的表达和意义。方法收集27例CHL,采用免疫组化SP法标记fascin抗体,观察fascin蛋白在CHL中R-S细胞的表达,并比较其与CD30、CD15表达的差异性。结果R-S细胞fascin的表达强度明显高于CD30和CD15。fascin蛋白在全部27例CHL R-S细胞胞浆中弥漫强阳性表达,阳性率为100%(27/27);CD30、CD15的表达强弱不等,阳性率分别为96.3%(26/27)、74.1%(20/27)。结论fascin蛋白是经典型霍奇金淋巴瘤R-S细胞高度敏感的标记物,它有助于诊断CHL,它的阴性表达具有排除CHL的意义。Objective To explore the expression of fascin of Reed-Sternberg cells （R-S cells） in classical Hodgkin lymphoma （CHL）. Methods Twenty-seven cases of CHL were immunohistochemically stained for fascin with SP method. The expression of fascin of R-S cell was observed and compared with CD30 and CD15 staining in RS cells. Results In all cases of CHL,the observed fascin staining in the RS cells was much stronger than that for CD30 and CD15. All 27 cases （100%） of CHL showed an intensely diffuse cytoplasmic staining, while 26 （96.3 % ） for CD30 and 20 （74.1%） of 27 cases for CD15 showed weak-to-strong expression. Conclusion Fascin is a highly sensitive marker for Reed-Sternberg cells,which is helpful to diagnosis of classical Hodgkin lymphoma and has a high negative predictive value for diagnosis of classical Hodgkin lymphoma.

关 键 词：经典型霍奇金淋巴瘤 FASCIN 免疫组化 R-S细胞 

分 类 号：R733.1[医药卫生—肿瘤] R730.21[医药卫生—临床医学]