N^4-取代缩氨基硫脲衍生物的合成  

Synthesis and Antibactiral of Derivatives of N 4 Substituted Thiosemicarbazone

作　　者：钟蒙[1,2] 文晓霞[1,2] 李忠[1,2] 陈建设[1,2] 辛义周[1,2] 郭佃顺[1,2] 

机构地区：[1]山东医科大学药学系 [2]山东师范大学化学系

出　　处：《合成化学》1997年第3期305-308,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以Ｎ４－取代氨基硫脲与尿嘧啶－１－乙醛反应，合成了６种Ｎ４－取代氨基硫脲衍生物，并进行了抗菌活性测试。结果表明，当Ｎ４－取代基为对氯苯基（Ⅲ６）时，具有较高的抑制枯草杆菌活性，对八叠球菌、白色念珠菌、黄曲霉菌亦有一定活性。Six N 4 substituted thiosemicarbazones were prepared by condensation of N 4 substituted thiosemicarbazide with uracil 1 acetaldehyde. The inhibiting activities of all the compounds against six kinds of bacteria and two kinds of fung were determined preliminarily. The results showed that compound Ⅲ 6 possessed higher inhibiting activity against B. Subtilis, and some inhibiting activities against S. Lutea, M. Albicans and A. Flavus.

关 键 词：缩氨基硫脲 衍生物 抗菌活性 硫脲 

分 类 号：O623.543[理学—有机化学]