硒化紫球藻胞外多糖毒性及抗氧化活性的研究  

Study on the toxicities and the antioxidative activities of selenium exopolysaccharide from Porphyridium sp (Se-PSP)

作　　者：朱劲华[1] 王敏[2] 张威[1] 李朝军[2] 张成武[2] 

机构地区：[1]江苏职工医科大学,江苏南京210029 [2]南京师范大学江苏省分子医学生物技术重点实验室,江苏南京210097

出　　处：《中国海洋药物》2008年第4期48-51,共4页Chinese Journal of Marine Drugs

摘　　要：目的研究硒化紫球藻胞外多糖的毒性及抗氧化活性。方法采用在培养液中添加亚硒酸,制备硒化紫球藻胞外多糖(Se-PSP);在体外培养条件下,测量其对细胞代谢活力的抑制率;建立小鼠动物模型,测量各项抗氧化功能指标。结果Se-PSP对LO-2的半抑制浓度为80μg·mL^(-1);Se-PSP(80,160 mg·kg^(-1))对小鼠不仅无毒性,而且还有促进其生长、抗氧化等保健功能。结论Se-PSP在80,160 mg·kg^(-1)低浓度范围内,可以发挥硒多糖的抗氧化等活性。Objective To study the toxicities and the antioxidation effects of selenium exopo- lysaccharide form porphyridium sp （Se-PSP）. Mothods Se-PSP was obtained by adding selenious acid in culture liquid, the restraining-ratio of Se-PSP to cell metabolism was measured in vitro, and various indexes of antioxidation effect of Se-PSP were studied by a rat model. Results and Conclusion The results showed that half-restraining concentration of Se-PSP to LO-2 was 80μg·mL^-1 , and that Se-PSP was helpful to the rat growth and had antioxidation effect in low concentration.

关 键 词：硒 紫球藻 胞外多糖 毒性 抗氧化性 

分 类 号：R931.711[医药卫生—生药学] R99[医药卫生—药学]