人类蛋白质互作网络hub蛋白与其结构域关联分析  

Association Analysis on hubs and Domains in Human Protein-protein Interaction Network

作　　者：王靖[1] 李霞[1] 朱明珠[1] 肖雪[1] 

机构地区：[1]首都医科大学生物医学工程学院,中国北京100069

出　　处：《生命科学研究》2008年第3期253-256,共4页Life Science Research

基　　金：国家自然科学基金资助项目(30571034;30370798);国家863项目(2007AA02Z329);2006年北京市新世纪百千万人才工程;北京市教育委员会科技发展计划项目(KM20060025011)

摘　　要：hub蛋白质作为参与较多互作的"中心蛋白",在实现蛋白质功能和生命活动中发挥着关键作用.而结构域作为蛋白质上的基本功能区域,决定着蛋白质功能及蛋白质互作的情况.互作网络中hub蛋白质和结构域对于蛋白质功能的实现均起到决定性的作用.对蛋白质互作与结构域的关系分析表明,蛋白质互作与结构域之间存在着密切的联系.对人类蛋白质互作网络中的hub蛋白与结构域进行关联分析,探讨hub蛋白及其互作partner与结构域数目之间的关系,并通过hub蛋白质之间的互作对相应结构域的关系进行进一步的论证.As a group of ＂core proteins＂ which interact with many other proteins, hub proteins played a key role in protein functions and life activities. Meanwhile, domain was known as a part of protein sequence and structure, and thus could decide functions and interplays of proteins. Therefore, both protein hubs and domains were decisive for realizing protein functions. The previous analysis showed there was an intimate relationship between protein-protein interactions and domains. Association analysis on hubs and domains in human protein-protein interaction network were focused and the relevance between hub-and-partners and number of domains were probed. Then, a further demonstration based on this relationship were made.

关 键 词：蛋白质互作网络 连通度 hub蛋白质 互作伙伴(partner) 结构域 

分 类 号：R31[医药卫生—基础医学]